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A Journal of Postdoctoral Research.
 
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    ISSN : 2328-9791
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SRC-3 : a transcriptional coactivator and therapeutic target in cancer
     
 
Fei Yan and Shaofang Wu
Baylor College of Medicine
1Baylor College of Medicine, Houston, TX, USA. 2The University of Texas MD Anderson Cancer Center, Houston, TX, USA
fei.yan@bcm.edu

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), a transcription coactivator, is frequently overexpressed in multiple type of human cancers, including breast, ovarian, prostate, pancreatic, lung, and colorectal cancers. SRC-3 not only interacts with multiple nuclear hormone receptors but also broad-spectrum of non-nuclear-receptor transcription factors to enhance their transcriptional activities. Furthermore....

 
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