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A Journal of Postdoctoral Research.
 
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    ISSN : 2328-9791
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The Mediation of Hepatic Lipogenesis Through Estrogens
     
 
Colette N. Miller, Mary Anne Della-Fera, Clifton A. Baile
University of Georgia
1Department of Foods and Nutrition, University of Georgia, Athens, Georgia; 2Animal and Dairy Science, University of Georgia, Athens, Georgia
cnmiller@uga.edu

Estrogens have been shown to protect against various diseases and disastrous metabolic consequences of poor diets. Although a large body of research demonstrates estrogen’s ability to control food intake, adipogenesis, and oxidative stress, research regarding the effects of estrogens on hepatic lipogenesis, steatosis, and non-alcoholic fatty liver disease is only now accumulating. Estrogen deficiency in both human and rodent models directly results in the upregulation of hepatic lipogenic signaling - in both serum and hepatic triglyceride content - which leads to the development of fatty liver. In all models, estrogen replacement completely reverses these outcomes. Similar to the endogenous estrogen hormone, plant-derived phytoestrogens also appear to have beneficial effects related to prevention of hepatic lipogenic signaling and steatosis in rodent models. Additionally,......................

 
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