A Journal of Postdoctoral Research.
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Th17/Treg imbalance in murine cystic fibrosis and IDO deficiency
Flaminia Malvezzi-Campeggi
Fondazione per la Ricerca sulla Fibrosi Cistica
Ospedale Maggiore, Piazzale Stefani 1, 37126 Verona, Italy.
Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by a mutation in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). This protein is required to regulate the components of sweat, digestive fluids, and mucus. CFTR regulates the movement of chloride and sodium ions across epithelial membranes, therefore patients suffering from CF are characterized by abnormal transport of chloride and sodium across an epithelium which leads to thick, viscous secretions. Difficulty when breathing is the most serious symptom and results from frequent lung infections that are treated with antibiotics and other medications....

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