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QSAR Study of Thiophene-Anthranilamides Based Factor Xa Direct Inhibitors
Preetpal S Sidhu<br />
Department of Chemistry and Biochemistry, UW, Milwaukee, WI 53211, USA<br />
Preetpal S Sidhu
University of Wisconsin
Department of Chemistry and Biochemistry, UW, Milwaukee, WI 53211, USA
preetpalsidhu@gmail.com
QSAR studies were performed to understand the structure activity relationship (SAR) and to build the computational model to predict newer inhibitors with improved potency. In this study, a library of thiophene-anthranilamide based inhibitors of factor Xa was used to develop QSAR model. The library was divided into two sets: Training and Test sets. QSAR Model consists of four descriptors with R-square value of 0.80. Based on the statistical parameters, this model can be used to predict the newer inhibitors with improved pharmacological profile.
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