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  Dr. CATHERINE LOC CARRILLO  
 
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Title : Dr.
First Name : CATHERINE
Last Name : LOC CARRILLO
University/Institution : University of Utah
Phone # : 8015740088
Email ID : c.loc.carrillo@hsc.utah.edu
City : Salt Lake City
Country : United States
State : Utah
Zipcode : 84148
Department : Orthopaedics
Company Name :
Area of Research
Infection, Phage Therapy
Area of Expertise
Microbiology
Brief Description of Research Interest :
My goal is to conduct well-controlled, impartial research to investigate the possibilities of applying bacteriophages as biocontrol agents to clinically problematic infections, with particular emphasis on antibiotics resistant bacteria.  My research for the past 10 years has involved looking at how phages (bacterial viruses) can be applied for the reduction and eradication of problematic bacteria. 
My long-term goals lie in gaining a better understanding of the microbial parameters necessary to cause infection and practical ways to diagnose and treat them.  I am particularly interested in investigating what happens during the transition of acute infection into chronic osteomyelitis.  The rat model we develop could be used for this research.  There are no current definitive diagnostic measures of differentiating between acute and chronic bone infections, and the importance in differentiating between the two stages would affect the type of treatment regime used to treat the infection.  Chronic osteomyelitis generally requires surgical intervention and prolonged antibiotic treatment due to the refractory characteristics of biofilms forming within the infected bone, and it could prove advantageous to determine if an infection has developed into it’s chronic stage as the appropriate intervention strategies can be used as early as possible.  If the phage therapy does not prove efficacious in treating osteomyelitis, I would be interested in seeking other alternative therapeutics that could be used in conjunction with or as alternative to antibiotics, which appear to now have a very finite life span before their use becomes obsolete due to the rapid development of antibiotic resistant bacteria.
Representative Publications :

1.     Connerton, P.L., Loc Carrillo,C.M., Swift, C., Dillon, E., Scott, A., Rees, C.E.D., Dodd, C.E.R., Frost,J. & Connerton, I.F. (2004). Longitudinal study of Campylobacter jejuni bacteriophage and their hostsfrom broiler chickens. Applied and Environmental Microbiology, 70(7), 3877-3883.

2.     Loc Carrillo, C., Atterbury, R.J.,El-Shibiny, A., Connerton, P.L., Dillon, E., Scott, A. & Connerton, I.F.(2005). Bacteriophage therapy to reduce Campylobacter jejunicolonization of broiler chickens. Applied and Environmental Microbiology, 71(11),6554-6563.

3.      Townsend, S., Caubilla Barron, J., LocCarrillo, C. & Forsythe, S. (2007). The presence of endotoxin inpowdered infant formula milk and the influence of endotoxin and Enterobacter sakazakii on bacterial translocation in the infant rat. FoodMicrobiology, 24(1), 67-74.

4.      Loc Carrillo, C., Connerton, P.L., Pearson,T. & Connerton, I.F. (2007). Free-range layer chickens as a source ofCampylobacter bacteriophage. Antonie Van Leeuwenhoek, Oct; 92(3),275-84.

5.  Scott, A.E., Timms, A.R., Connerton, P.L., Loc Carrillo, C., Adzfa Radzum, K. & Connerton, I.F. (2007).Genome dynamics of Campylobacter jejuni in response tobacteriophage predation. PLoS Pathogen,Aug 24; 3(8), e119.

6.      Caubilla-Barron J., Hurrell, E., Townsend, S., Cheetham, P., Loc-Carrillo, C., Fayet, O., Prère,M.F. & Forsythe, S.J. (2007). Genotypic and phenotypic analysis of Enterobactersakazakii strains from an outbreak resulting in fatalities in a neonatalintensive care unit in France. Journal of Clinical Microbiology, Dec; 45(12), 3979-85.

7.      Townsend, S.M., Hurrell, E., Caubilla-Barron,J., Loc Carrillo, C.& Forsythe, S.J. (2008). Characterization of an extended-spectrum beta-lactamaseEnterobacter hormaechei nosocomial outbreak, and other Enterobacter hormaecheimisidentified as Cronobacter (Enterobacter) sakazakii.Microbiology, 154 (Pt12), 3659-67.

8.      Loc-CarrilloC and Abedon S. (2011). Pros and cons of phage therapy.Bacteriophage, 1 (2): 1-4.

9.  Sinclair, KD., Pham, TX., Farnsworth, RW., Williams, DL., Loc-Carrillo, C., Home, LA.,Ingebretsen, S. & Bloebaum, RD. (2012). Development of a Broad SpectrumPolymer Released Antimicrobial Coating for the Prevention of PerioperativeDevice-Related Infections. Journal of Biomedical Materials Research Part A - In press.
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