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Dr. ROHINI VISHWANATHAN
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Address 1
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Address 2
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Title
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Dr.
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First Name
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ROHINI
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Last Name
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VISHWANATHAN
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University/Institution
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JM USDA Human Nutrition Research Center on Aging at Tufts University
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Email ID
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rohini.vishwanathan@tufts.edu
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City
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Boston
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Country
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United States
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State
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Massachusetts
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Zipcode
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02111
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Department
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Carotenoids and Health
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Company Name
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Area of Research
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Role of carotenoids in vision and cognition
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Area of Expertise
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Macular carotenoids - Lutein and Zeaxanthin
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Brief Description of Research Interest :
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Investigating the role of carotenoids in human brain. Research findings:
---Significant association between retinal lutein and zeaxanthin and brain lutein and zeaxanthin in nonhuman primates. Macular pigment density could thus be used as a biomarker to assess brain lutein and zeaxanthin status. Currently evaluating this relationship in matched human retina and brain tissues.
--Preferential uptake of xanthophylls, especially lutein, over carotenes in the cerebellum and regions of the cerebral cortex of human brain in both older adults and infants in the first year of life.
--Significant cross sectional association of brain lutein with pre-mortem cognitive function measures in older adults. Significant decrease in brain lutein, zeaxanthin and beta-carotene in decedents with pre-mortem mild cognitive impairment compared to those with normal cognitive function. Currently examining the relationship between brain fatty acids and cognitive function.
--Significant relationship between brain cryptoxanthin and pre-mortem physical function measures in older adults.
Ongoing vision-related research --Meta-analysis and systematic review to evaluate nutrients beneficial in the prevention and/or treatment of AMD, cataract and glaucoma.
--Bioavailability of fat- and water- soluble nutrients (vitamins C and E, beta-carotene, zinc and copper) contained in soft gel capsules versus tablets in a pilot study.
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Representative Publications :
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JOURNAL ARTICLES
- Vishwanathan R, Neuringer M, Snodderly DM, Schalch W, Johnson EJ. Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates. Nutritional Neuroscience 2012. DOI: 10.1179/1476830512Y.0000000024.
- Vishwanathan R, Gendron CM, Goodrow EF, Wilson TA, Nicolosi RJ. Increased consumption of dietary cholesterol, lutein, and zeaxanthin as egg yolks does not decrease serum concentrations and lipoprotein distribution of other carotenoids, retinol, and tocopherols. Nutrition Research 2010;30:747-755.
- Vishwanathan R, Wilson TA, Nicolosi RJ. Bioavailability of a nanoemulsion of lutein is greater than a lutein supplement. Nano Biomed Eng 2009; 1(1): 38-49.
- Vishwanathan R, Goodrow EF, Wilson TA, Nicolosi RJ. Consumption of 2 and 4 egg yolks/d for 5 weeks increases macular pigment concentrations in older adults with low macular pigment taking cholesterol lowering statins. Am J Clin Nutr. 2009; 90: 1272-9.
- Goodrow EF, Wilson TA, Houde SC, Vishwanathan R, Scollin PA, Handelman GJ and Nicolosi RJ. Consumption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults without altering serum lipid and lipoprotein cholesterol concentrations. J. Nutr. 2006; 136: 2519-2524.
BOOK CHAPTERS
- Vishwanathan R and Johnson EJ. Chapter 14: Lutein and Zeaxanthin in Eye Health. Carotenoids and Human Health. Editor: Sherry A. Tanumihardjo, Ph.D. Springer publications (in press).
- Vishwanathan R and Johnson EJ. Chapter 56: Eye Disease. Present Knowledge in Nutrition, 10th edition. Editors: John Erdman, Ph.D., Ian Macdonald, Ph.D., and Steven Zeisel, Ph.D. ILSI and John Wiley & Sons.
ABSTRACTS
- Johnson EJ, Vishwanathan R, Scott TM, Schalch, Wittwer J, Hausman DB, Davey A, Johnson MA, Green RC and Poon LW. Serum carotenoids as a biomarker for carotenoid concentrations in the brain. FASEB J. 2011;25:344.2
- Johnson EJ, Vishwanathan R, Schalch W, Poon LW, Wittwer J, Johnson MA, Hausman DB, Davey A, Green RC, Gearing M, Woodard J, Nelson P, Miller S and Scott TM. Brain levels of lutein (L) and zeaxanthin (Z) are related to cognitive function in centenarians. FASEB J. 2011;25:975.21.
- Goodrow EF, Vishwanathan R, Wilson TA, Nicolosi RJ. C-reactive protein (CRP) levels are not affected in participants consuming the equivalent of 2 and 4 egg yolks a day while on cholesterol-lowering medication. FASEB J. 2007; 21(6): A1088.
PRESENTATIONS
ORAL
- Xanthophylls in the infant brain. Carotenoids Research Interactive Group (CARIG) Symposium at Experimental Biology 2012, San Diego, CA.
- Relationship between brain lutein (L) and zeaxanthin (Z) and retinal L and Z in humans. Experimental Biology 2012, San Diego, CA.
- Brain carotenoids and physical function in the very old. 16th International Symposium on Carotenoids, Krakow, Poland, 2011.
- Lutein (L) and Zeaxanthin (Z) levels in retina related to levels in the brain. Experimental Biology 2011, Washington DC (Abstract in FASEB J. 2011;25:344.1).
- Lutein and zeaxanthin status: Relationships to cognition in the elderly. Seminar series at Jean Mayer USDA HNRCA at Tufts University, Boston, MA, 2011
- Serum lutein and zeaxanthin response to consumption of two and four egg yolks in older adults on cholesterol lowering medication. APHA Annual meeting, San Diego, CA, 2008.
POSTER
- Distribution of carotenoids in infant brain. 16th International Symposium on Carotenoids, Krakow, Poland, 2011.
- Macular lutein concentration is related to brain lutein concentration in primates. Macular Carotenoids and AMD, Cambridge, UK, 2011.
- Lutein uptake is greater from egg yolks compared to nanoemulsions in Caco-2 cells. Experiment Biology 2011, Washington DC (Abstract in FASEB J. 2011;25:975.22).
- Lutein and zeaxanthin concentrations in the serum and brain are related to cognitive function in older adults. New England Science Symposium, Harvard Medical School, Boston, MA, 2011.
- Consumption of 2 and 4 egg yolks/d for 5 weeks each increases macular pigment density in older adults with low macular pigment taking cholesterol lowering statins. New Developments in Carotenoids Research, Jean Mayer USDA HNRCA at Tufts University, Boston, MA, 2011.
- Bioavailability of a nanoemulsion of lutein is greater than a lutein supplement. New England Science Symposium, Harvard Medical School, Boston, MA, 2010.
- Bioavailability of a nanoformulation of lutein is greater than a lutein supplement. Institute of Food Technologists Annual Meeting and Food Expo, Anaheim, CA, 2009.
- Macular pigment responses to consumption of foods containing 2 and 4 egg yolks a day in older adults on cholesterol lowering medication. Twelfth Annual Vision Research Conference - Mechanisms of Macular Degeneration, Fort Lauderdale, FL, 2009.
- Macular pigment responses to consumption of foods containing 2 and 4 egg yolks a day in older adults on cholesterol lowering medication. New England Science Symposium, Harvard Medical School, Boston, MA, 2009.
- Consumption of menus containing the equivalent of two and four egg yolks in older adults on cholesterol lowering medication is associated with significant changes in serum lutein and zeaxanthin concentrations and macular pigment optical density (MPOD). Experimental Biology 2007, Washington DC (Abstract in FASEB J. 2007; 21(6): A1087).
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