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  Dr. KIM WILKINSON  
 
Address 1 :
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Title : Dr.
First Name : KIM
Last Name : WILKINSON
University/Institution : Dana-Farber Cancer Institute
Email ID : kwilkinson9@gmail.com
City : Boston
Country : United States
State : Massachusetts
Zipcode : 02129
Department : CIID
Company Name :
Area of Research
Alzheimer's disease, innate immunity
Area of Expertise
cell biology, receptor mediated cell signalling, innate immunity
Brief Description of Research Interest :

I am interested in determining the role of macrophage scavenger receptors in the pathology of Alzheimer’s disease.  I utilise various scavenger receptor knock-out mouse models of disease to try and understand the pathological signalling mechanism during disease development. 

Representative Publications :

K Wilkinson, N DeMarse, N Kingery, J El Khoury (2012).  Characterization of the affinity of CD36 toamyloid-β and to the CD36 inhibitor ursolic acid.  Manuscript in preparation.

 

KWilkinson and J El Khoury (2012).  Microglial Scavenger Receptors and their Roles inthe Pathogenesis of Alzheimer’s Disease.   International Journal of Alzheimer’sDisease, Microglia in Alzheimer's Disease Special Issue, Volume 2012.

 

KWilkinson, N Kingery, J El Khoury (2012).  Decreased AD-like pathology in PS1APP-CD36-/-mouse brains due to upregulation of neprilysin expression and control ofamyloid-β plaque formation.  Manuscriptin preparation.

 

D Frenkel*, KWilkinson* (Equal contributions),SE Hickman, L Zhao, TK Means, L Puckett,  D Farfara, HL Weiner, J El Khoury (2012).  Scara1 deficiencyimpairs clearance of amyloid-β by mononuclear phagocytes and acceleratesprogression of Alzheimer’s-like disease. Under review at Nature Communications.

 

K Wilkinson, JD Boyd, M Glicksman, KJ Moore, J EL Khoury(2011).  A high content screen identifiesinhibitors of amyloid-β and its receptor CD36. Journal of Biological Chemistry.  286, 34914–34922.

 

CR Stewart*,LM Stuart*, K Wilkinson* (Equal contributions), J van Gils, J Deng, A Halle, KJRayner,  L Boyer, R Zhong, WA Frazier, J EL Khoury, DT Golenbock, KJ Moore(2010).  CD36 ligands promote sterileinflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nature Immunology, 11, 155 – 161.

·        Article featured in Research Highlights of Nature Reviews Immunology, 10, 82 (2010).

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