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  Dr. AMIT TIWARI  
 
Address 1 :
Address 2 :
Title : Dr.
First Name : AMIT
Last Name : TIWARI
University/Institution : Mount Sinai School of Medicine
Phone # : 212-241-8201
Email ID : amit.tiwari@mssm.edu
City : NYC
Country : United States
State : New york
Zipcode : 10029
Department : Pharmacology and Systems Therapeutics
Company Name :
Area of Research
Pharmacology, Dug discovery, Drug Resistance
Area of Expertise
Pharmacology, Dug discovery, Drug Resistance, OncoPharmacology
Brief Description of Research Interest :

Dr. Amit K. Tiwari research is focused on overcoming drug resistance in cancer. Dr. Tiwari has extensively characterized the drug resistance mechanism of novel anticancer drugs and has shown ways to improve cancer chemotherapy. In addition, Dr. Tiwari is involved in Pharmacokinetic/Pharmacodynamic driven anticancer drug development. in addition to understanding the molecular determinants in drug disposition, his efforts are directed towards improving brain cancer chemotherapy.


Representative Publications :

Tiwari AK, Sodani K, DaiCL, Abuznait AH, Singh S, Xiao ZJ, Vispute S, Patel P, Talele TT, Fu LW,Kaddoumi A, Gallo JM, Chen ZS. Nilotinibpotentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrugresistance xenograft models. CancerLett. 2012 Oct 9. [Epub ahead of print] PMID: 23063650

Chen ZS and TiwariAK. Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy andhuman genetic diseases. FEBS J. 2011 Sep;278(18):3226-45. Epub2011 Aug 1. PMID: 21740521

Tiwari AK, Yang DH, and ChenZS.  Molecular mechanisms of methotrexateresistance. Nova Science Publishers, Inc. ISBN – 978-1-62100-596-4, 2012

Shi Z, TiwariAK, Shukla S, Robey RW, Singh S, Kim IW, Bates SE, Peng XX, Abraham I,Ambudkar SV, Talele TT, Fu LW, Chen ZS. Sildenafil reverses ABCB1-and ABCG2-mediated chemotherapeutic drug resistance. Cancer Res, 2011 Apr 15;71(8):3029-41. Epub 2011 Mar 14.  PMID: 21402712

Tiwari AK, Sodani K, Dai CL, Ashby C, Chen ZS. Revisitingthe ABCs of Multidrug Resistance in Cancer Chemotherapy. Curr Pharm Biotechnol. 2011 Apr 1;12(4):570-94.  PMID: 21118094

Tiwari AK, Sodani K, Wang SR, Kuang YH, Ashby CR, Jr., Chen Xand Chen ZS. Nilotinib (AMN107, Tasigna) reverses multidrug resistance byinhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol 2009 Jul 15;78(2):153-61. Epub 2009 Apr 11. PMID: 19427995

Tiwari AK, Xin A, Chen ZS. Therole of stem cell markers in multidrug resistance mediated by ABC transporters.Leukemia Res 34,696–697, 2010 doi:10.1016/j.leukres.2009.12.007.  PMID:20061021

Dai CL, Tiwari AK*, Wu CP, Su XD, Wang SR, Liu DG, Ashby CR, Jr.,Huang Y, Robey RW, Liang YJ, Chen LM, Shi CJ, Ambudkar SV, Chen ZS and Fu LW.Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells byinhibiting the activity of ATP- binding cassette subfamily B member 1 and Gmember 2. Cancer Res 2008 Oct 1;68(19):7905- 14 (*Co-FirstAuthor). PMID: 18829547 

 

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