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Dr. ANAND KRISHNAN
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Address 1
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Address 2
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Title
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Dr.
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First Name
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ANAND
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Last Name
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KRISHNAN
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University/Institution
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Hotchkiss Brain Institute/University of Calgary
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Phone #
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4039263397
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Email ID
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anandkrishn@gmail.com
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City
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Calgary
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Country
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Canada
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State
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Alberta
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Zipcode
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T2N4C2
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Department
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Clinical Neurosciences
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Company Name
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Area of Research
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Peripheral nerve regeneration
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Area of Expertise
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Cancer biology, regenerative medicine
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Brief Description of Research Interest :
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After completing my PhD in cancer biology, my current research is focused in the field of regenerative medicine. During my cancer biology program I learned how deregulation in protein homeostasis affects progression of malignancy in several tissue types. My postdoctoral work in Dr.Zochodne’s lab utilizes this information towards peripheral nerve regeneration events. My work progresses through siRNA and small molecule based therapeutic approaches aimed at peripheral nerve regeneration. I routinely perform sciatic nerve crush and transection injury models in rats and additionally engaged with techniques like primary culture of adult rat sensory neurons, immunocytochemistry, immunoblotting and advanced microscopy. Understanding the basics of tissue growth and regeneration can also bring light to the 'critical points of errors' leading to carcinogenesis. Thus, I strongly believe that the knowledge acquired from regeneration research would help me exchange scientific information to the ‘understanding of carcinogenesis’ as well.
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Representative Publications :
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Christie KJ *, Krishnan A *, Martinez JA, Purdy K, Singh B, Eaton S, Zochodne D. A Novel Strategy to Enhance Adult Nerve Regeneration through the knockdown of Retinoblastoma Protein. Nat Commun. 2014 Apr 22;5:3670 (*equal contribution)
Krishnan A, Zochodne DW. Targeting retinoblastoma protein offers therapeutic opportunities for peripheral nerve injury. Future Neurology (Editorial; in press).
Singh B, Singh V*, Krishnan A*, Koshy K, Martinez J, Cheng C, Almiquist C, Zochodne DW. Regeneration of diabetic axons is enhanced by selective knockdown of phosphatase and tensin homolog deleted on chromosome ten. Brain. 2014 Apr;137(Pt 4):1051-67. (*equal contribution)
Jagadeeshan S, Ramia YK, Singhal M, Subramanian A, Mavuluri J, Arivazhagan L, Arivazhagan R, Baskar G, Ravi M, Joseph LD, Sadasivan K, Krishnan A, Nair SA, Venkatraman G and.Rayala SK.Transcriptional Regulation of Fibronectin by Pak1 Modulate Pancreatic tumorigenesis. Oncogene. 2014 Feb 24. doi: 10.1038/onc.2013.576
Cheng C, Singh V*, Krishnan A*, Kan M, Martinez J.A, Zochodne D. 2013. Loss of Innervation and Axon Plasticity Accompanies Impaired Diabetic Wound Healing. PLoS One. 8(9); e75877. (*equal contribution)
Krishnan A. 2013. Neuregulin-1 type I: A hidden power within Schwann cells for triggering peripheral nerve remyelination. Sci. Signal. 6, jc1
Krishnan A, Vivek.R.Gopinath, Ajit Johnson, S. Asha Nair and M.Radhakrishna Pillai. 2013. Cell cycle analysis and micronuclei frequency reveals G0/G1 blockers as weak micronuclei inducers. Drug Chem Toxicol. 39:249-254
Singh B, Xu Y, McLaughlin T, Singh V, Martinez JA, Krishnan A, Zochodne DW. 2012. Resistance to trophic neurite outgrowth of sensory neurons exposed to insulin. J Neurochem. 121:263-76
Krishnan V, Krishnan A, Remya R, Ravikumar KK, Asha Nair S, Shibli SM, Varma HK, Sukumaran K, Jyothindra Kumar K. 2011. Development and Evaluation of Two PVD Coated Beta Titanium Orthodontic Archwires for Fluoride Induced Corrosion Protection. Acta Biomater. 7:1913-1927
Krishnan A, Nair SA, Pillai MR. 2010. Loss of cks1 homeostasis deregulates cell division cycle. J Cell Mol Med. 14: 154 – 164.
Ramshid PK, Jagadeeshan S, Krishnan A, Mathew M, Nair SA, Pillai MR. 2010. Synthesis and in vitro evaluation of some isatin-thiazolidinone hybrid analogues as anti-proliferative agents. Med Chem.6:306-312
Krishnan A, Hariharan R, Nair SA, Pillai MR. 2008. Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 75:1924-1934
Krishnan A, Nair SA, Pillai MR. 2007. Biology of PPAR gamma in cancer: a critical review on existing lacunae. Curr Mol Med. 7:532-540
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Resume
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