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    ISSN : 2328-9791
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  Dr. CIGDEM AYDIN  
 
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Title : Dr.
First Name : CIGDEM
Last Name : AYDIN
University/Institution : University of Michigan
Email ID : caydin@umich.edu
City : ann arbor
Country : United States
State : Michigan
Zipcode : 48109
Department : molecular and behavioral neuroscience institute
Company Name :
Area of Research
molecular and behavioral neuroscience
Area of Expertise
addiction
Brief Description of Research Interest :
Investigation of neurobiological basis of individual differences in propensity to relapse to psychostimulants, using a rat model of the novelty-seeking phenotype. 
Representative Publications :

Bhatti, A.S., Aydin, C., Oztan, O., Ma, Z., Tao, R., Isgor, C. (2009). Effects of cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5HT. Psychopharmacology (Berl) 203(1):23-32.

Aydin, C., Oztan, O., Isgor, C. (2011) Vulnerability to nicotine abstinence-related social anxiety-like behavior: Molecular correlates in neuropeptide Y, Y2 receptor and corticotropin releasing factor. Neurosci Lett 490(3):220-225.

Aydin C., Oztan O., Isgor, C. (2011) Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype. Behav Brain Res 222(2):332-41

Oztan, O., Aydin, C., Isgor, C. (2011) Chronic variable physical stress during the peripubertal-juvenile period causes differential depressive and anxiogenic effects in the novelty-seeking phenotype: functional implications for hippocampal and amygdalar brain-derived neurotrophic factor and the mossy fibre plasticityNeuroscience; Epub

Oztan, O., Aydin, C., Isgor, C. (2011) Stressful environmental and social stimulation in adolescence causes antidepressant-like effects associated with epigenetic induction of the hippocampal BDNF and mossy fibre sprouting in the novelty-seeking phenotype. Neurosci Lett; Epub

Aydin C., Oztan O., Isgor C. (2012) Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251. Neuropharmacology.63(8):1335-45.

Aydin C., Oztan O., Isgor C. (2012) Long-term effects of juvenile nicotine exposure on abstinence-related social anxiety-like behavior and amygdalar cannabinoid receptor 1 (CB1R) mRNA expression in the novelty-seeking phenotype. Behav Brain Res. 228(1):236-9.

Aydin C., Oztan O., Isgor C. (2013) Hippocampal Y2 receptor-mediated mossy fiber plasticity is implicated in nicotine abstinence-related social anxiety-like behavior in an outbred rat model of the novelty-seeking phenotype (in preparation)

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