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A Journal of Postdoctoral Research.
 
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    ISSN : 2328-9791
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  Dr. MI CAI  
 
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Title : Dr.
First Name : MI
Last Name : CAI
University/Institution : Novartis Institutes for BioMedical Research, Inc.
Phone # : 6178717078
Email ID : kuailemimicai@gmail.com
City : Cambridge
Country : United States
State : Massachusetts
Zipcode : 02139
Department : Developmental and Molecular Pathway
Company Name :
Area of Research
Use genome editing tools (Zinc Finger Nuclease, TALENs, CRISPR, etc.) to build disease models for both mechanistic studies and drug discovery.
Area of Expertise
stem cell and developmenal biology, genome editing, disease modeling
Brief Description of Research Interest :
As a Presidential Postdoctoral Fellow at Novartis Institutes for BioMedical Research, Inc., I am currently working on using genome editing tools (Zinc Finger Nuclease, TALENs, CRISPR, etc.) to build disease models for both mechanistic studies and drug discovery. These tools can also be used for gene therapy. I received my Ph.D.in Molecular Cell Biology from Washington University in St. Louis. My doctoral research focused on using embryonic stem cell model to dissect the transcriptional basis of cardiovascular and hematopoietic development. 
Representative Publications :

Cai M, Langer EM, Gill JG, SatpathyAT, Albring JC, KC W, Murphy TL, and Murphy KM. (2012) Dual actions of Meis1 inhibit erythroid progenitordevelopment and sustain general hematopoietic cell proliferation. Blood 120(2):335-46.

Gill JG, Langer EM, Lindsley RC, Cai M, Murphy TL, Murphy KM. (2012) Snailpromotes the cell-autonomous generation of Flk1+ endothelial cells throughthe repression of the microRNA-200 family. Stem Cells Dev. 21(2):167-76.

Cai M, Gill JG, Murphy TL, Murphy KM.(2011) Studies of Mesp1 in earlydevelopment of mesodermal lineages. Abstract published at the International Society for Stem Cell Research 9th Annual Meeting.

Gill JG, Langer EM, Lindsley RC, Cai M, Murphy TL, Kyba M, Murphy KM. (2011)Snail and the microRNA-200 family act in opposition toregulate epithelial-to-mesenchymal transition and germ layer fate restriction indifferentiating ESCs. Stem Cells. 29(5):764-76.

LindsleyRC, GillJG, MurphyTL, LangerEM, Cai M,MashayekhiM, WangW, NiwaN, NerbonneJM, KybaM, MurphyKM. (2008) Mesp1 coordinatelyregulates cardiovascular fate restriction and epithelial-mesenchymal transitionin differentiating ESCs. CellStem Cell. 3(1):55-68.

Zhao C*, Cai M*, Zhang Y*,Liu Y,Sun R,Zhang N.(2007) Development of a microscopy-based assay for protein kinase Czetaactivation in human breast cancer cells. Anal Biochem. 362(1):8-15. (*denotes co-first authors) 

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