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A Journal of Postdoctoral Research.
 
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    ISSN : 2328-9791
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  Dr. BHARAT JAGANNATHAN  
 
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Title : Dr.
First Name : BHARAT
Last Name : JAGANNATHAN
University/Institution : University of California
Email ID : bharatj@berkeley.edu
City : Berkeley
Country : United States
State : California
Zipcode : 94720
Department : California Institute for Quantitative Biosciences
Company Name :
Area of Research
protein folding
Area of Expertise
protein biochemistry/biophysics
Brief Description of Research Interest :
  • Identified important structural features of protein-­‐protein and protein-­‐cofactor interactions crucialfor photosynthetic activity

  • Devised innovative strategies for comprehensively characterizing the mechanisms by whichproteins fold into their proper three-­‐dimensional structure

  • Developed a cutting-­‐edge technique using antibody-­‐antigen interactions to manipulate singleprotein molecules

  • Developed a method to simultaneously monitor multiple spectroscopic probes in proteins, whichwould report on long-­‐range allosteric effects

  • Elucidated the assembly pathways of large multi-­‐subunit protein complexes by identifying keyamino acids involved in binding

  • Discovered unique biological cofactors in membrane protein complexes that had eluded detectionfor twenty-­‐five years

  • Devised a novel method for quantifying toxic free radicals in biological systems by spin trapping 

Representative Publications :
  • Jagannathan, B. and Marqusee, S. (2013) Protein Folding and Unfolding Under Mechanical Force, Biopolymers, in press

  • Jagannathan, B., Elms, P., Bustamante, C. and Marqusee, S. (2012) Direct Observation of a Force-­ Induced Switch in the Mechanical Unfolding Pathway of a Protein, Proc. Nat. Acad. Sci. 109,17820-­17825

  • Jagannathan, B., Dekat, S., Golbeck, J.H. and Lakshmi, K.V. (2010) A Site Directed Spin Labeling Study of the Assembly of the PsaC Subunit in Photosystem I, Biochemistry 49, 2398-­‐2408

  • Jagannathan, B. and Golbeck, J.H. (2009) Understanding of the Binding Interface Between PsaC and the PsaA/PsaB Heterodimer in Photosystem I, Biochemistry 48, 5405-­‐5416

  • Jagannathan, B. and Golbeck, J.H. (2009) Breaking Biological Symmetry in Membrane Proteins: The Asymmetric Orientation of PsaC on the Photosystem I Core, Cell. Mol. Life Sci. 66, 1257-­‐1270

  • Jagannathan, B. and Golbeck, J.H. (2008) Unifying Principles in Homodimeric Type I Photosynthetic Reaction Centers: Properties of PscB and the FX, FA and FB Iron-­‐Sulfur Clusters in Green Sulfur Bacteria, Biochim. Biophys. Acta 1777, 1535-­‐1544 



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