Development of novel fluorination methods(mono, di and trifluoromethylations); using an industrial waste product andgreen-house gas, fluoroform (CF₃H), and other simple fluorinatingagents; to make commercially useful products.

Designing a “green” process (thatmeets 4 of 12 Green Chemistry principles) for C-C bond forming reactions usingmetal catalyzed cross-coupling approach.

PatentS:

·        Application:Surya Prakash, G. K.; Jog, P. V.;Batamack, P. T. D.; Olah, G. A. “Direct Trifluoromethylations usingTrifluoromethane.” US 2011-480092P (WO 2012148772) pp 42 (April 19^th, 2012).

Publications:

1.      Surya  Prakash, G. K.; Jog, P. V.; Batamack, P.T.D.; Olah, G. A. “Taming of Fluoroform (CF₃H):Direct Nucleophilic Trifluoromethylation of Silicon, Boron, Sulfur and CarbonBased Electrophiles” Science 2012, 338 (6112), 1324-1327.

2.       Wang, F.; Luo, T.; Hu, J.; Wang, Y.; Krishnan, H. S.; Jog, P. V.; Ganesh, S. K.; SuryaPrakash, G. K.; Olah, G. A. “ Synthesis of gem-Difluorinated Cyclopropane andCyclopropenes use TMS-CF₃ as a Difluorocarbene Source.” Angew.Chem. Int. Ed. 2011, 50 (31), 7153-7157.

3.       Surya Prakash G. K.; Jog, P. V.; Krishnan, H. S.; Olah, G. A. “A Domino Approach(Hydrolysis/Dehydrohalogenation/Heck Coupling) for the Synthesis of Styrene SulfonateSalt.” J. Am. Chem. Soc. 2011, 133,2140-2143. Also: Book ofAbstracts, 241^st ACS National Meeting, Anaheim, CA United States,March 27–31, 2011. ORGN-136

    4.       Jog, P. V.; Gin, M. S. “A Light-Gated Synthetic Ion Channel.” Org.Lett. 2008, 10,         3693-3696. Also: Book of Abstracts, 232^nd ACS NationalMeeting, San Francisco, CA, United States, September 10–14, 2006. ORGN-581