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Dr. JULIA KOEHLER LEMAN
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Address 1
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Address 2
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Title
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Dr.
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First Name
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JULIA
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Last Name
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KOEHLER LEMAN
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University/Institution
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Johns Hopkins University
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Email ID
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julia.koehler1982@gmail.com
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City
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Baltimore
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Country
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United States
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State
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Maryland
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Zipcode
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21218
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Department
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Chemical and Biomolecular Engineering
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Company Name
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Area of Research
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Structural Biology
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Area of Expertise
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Protein structure determination and modeling
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Brief Description of Research Interest :
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Structural biologist experienced in method development for membrane protein structure determination using computation and NMR spectroscopy. Computational method development and application of RosettaDock software. Expertise in various biochemical, structural biology, and computational techniques, with emphasis on machine learning algorithms, membrane protein expression, purification, NMR data acquisition, analysis, and structural modeling.
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Representative Publications :
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[1] G. Reuther, K.T. Tan, J. Koehler, C. Nowak, A. Pampel, K. Arnold, J. Kuhlmann, H. Waldmann, D. Huster, Structural model of the membrane-bound C terminus of lipid-modified human N-ras protein, Angew Chem Int Edit, 45 (2006) 5387-5390.
[2] J. Koehler, N. Woetzel, R. Staritzbichler, C.R. Sanders, J. Meiler, A unified hydrophobicity scale for multispan membrane proteins, Proteins, 76 (2009) 13-29.
[3] J. Koehler, R. Mueller, J. Meiler, Improved prediction of trans-membrane spans in proteins using an Artificial Neural Network, IEEE Comp. Intel. Bioinf. Comp. Biol., (2009) 68-74. (Best paper award)
[4] J. Koehler, E.S. Sulistijo, M. Sakakura, F.J. Kim, C.D. Ellis, C.R. Sanders, Lysophospholipid Micelles Sustain the Stability and Catalytic Activity of Diacylglycerol Kinase in the Absence of Lipids, Biochemistry, 49 (2010) 7089-7099.
[5] J. Koehler, J. Meiler, Expanding the utility of NMR restraints with paramagnetic compounds: Background and practical aspects, Prog Nucl Mag Res Sp, 59 (2011) 360-389.
[6] J. Koehler Leman, R. Mueller, M. Karakas, N. Woetzel,J. Meiler, Simultaneous prediction of protein secondary structure and trans-membrane spans, Proteins, 81 (2013) 1127-1140
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