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Dr. NOUSHIN NABAVI
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Address 1
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Address 2
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Title
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Dr.
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First Name
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NOUSHIN
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Last Name
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NABAVI
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University/Institution
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University of California, San Francisco
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Phone #
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226-316-2399
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Email ID
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noushin.nabavi@ucsf.edu
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City
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San Francisco
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Country
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United States
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State
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California
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Zipcode
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94107
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Department
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Molecular and Cellular Pharmacology
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Company Name
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Area of Research
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Liver, metabolism, drug, degradation
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Area of Expertise
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Cell and molecular Biology
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Brief Description of Research Interest :
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My research interest lies in the degradation of Cytochrome P450s. Cytochrome P450s belong to a large and diverse group of monooxygenase enzymes that are involved in catalyzing the oxidation of organic substrates such as lipids, hormones, and xenobiotic substrates. They are also known as the major enzymes involved in drug metabolism and bioactivation. My goal is to decipher the cellular and molecular mechanisms involved in the degradation of cytochrome P450s in human and rat hepatocytes.
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Representative Publications :
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Pustylnik S, Fiorino C, Nabavi N, Zappitelli T, da Silva R, Aubin JE, Harrison RE. EB1 Levels Are Elevated in Ascorbic Acid (AA)-stimulated Osteoblasts and Mediate Cell-Cell Adhesion-induced Osteoblast Differentiation. J Biol Chem. 2013 Jul 26; 288(30):22096-110.
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Durand M, Komarova SV, Bhargava A, Trebec-Reynolds DP, Li K, Fiorino C, Maria O, Nabavi N, Manolson MF, Harrison RE, Dixon SJ, Sims SM, Mizianty MJ, Kurgan L, Haroun S, Boire G, Lucena-Fernandes Mde F, de Brum-Fernandes AJ. Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: The In Vitro Osteoclast Differentiation in Arthritis study. Arthritis Rheum. 2013 Jan; 65(1):148-58.
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Nabavi N, Pustylnik S, Harrison RE. Rab GTPase Mediated Procollagen Trafficking in Ascorbic Acid Stimulated Osteoblasts. PLoS One. 2012; 7(9):e46265.
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Nabavi N, Khandani A, Camirand A, Harrison RE. Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion. Bone. 2011 Nov; 49(5):965-74.
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Durand M, Boire G, Komarova SV, Dixon SJ, Sims SM, Harrison RE, Nabavi N, Maria O, Manolson MF, Mizianty M, Kurgan L, de Brum-Fernandes AJ. The increased in vitro osteoclastogenesis in patients with rheumatoid arthritis is due to increased percentage of precursors and decreased apoptosis - the In Vitro Osteoclast Differentiation in Arthritis (IODA) study. Bone. 2011 Mar 1; 48(3):588-96.
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Hassanzadeh A, Nitsche M, Armstrong S, Nabavi N, Harrison R, Dixon SJ, Langbein U, Mittler S. Optical waveguides formed by silver ion exchange in Schott SG11 glass for waveguide evanescent field fluorescence microscopy: evanescent images of HEK293 cells. J Biomed Opt. 2010 May-Jun; 15(3):036018.
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Nabavi N, Urukova Y, Cardelli M, Aubin JE, Harrison RE. Lysosome dispersion in osteoblasts accommodates enhanced collagen production during differentiation. J Biol Chem. 2008 Jul 11; 283(28):19678-90.
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Resume
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