My long-term scientific goal is to focus on understanding the role of mitochondrial disease, and to investigate how mitochondria control various metabolic processes in our body. Further, I believe that not only diseases but also the drugs used in the treatment of diseases have a strong impact on mitochondrial function. By combining my knowledge of pharmacology and cell biology, and the research expertise I have gained through doctoral and postdoctoral training, I plan to study the effect of drugs on mitochondrial function during disease. As my independent research plan evolves, I would like to ask more translational questions that address individualized mitochondrial therapies. Studying the function of mitochondria during disease and the effects of drugs used to treat particular diseases will help enable clinical researchers to develop novel therapies for mitochondrial diseases.

Corrêa TD*, Vuda M*, Takala J, Djafarzadeh S, Silva E, Jakob SM Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Crit Care. 2013;17(1):R21. * Contributed equally

DjafarzadehS, Vuda M,Takala J, Jakob SM.  Effect of remifentanil onmitochondrial oxygen consumption of cultured human hepatocytes. PLoS One2012;7(9):e45195.

Correa TD*, VudaM*,  Reintam AB, Takala J,Djafarzadeh S, Dünser M, Silva E, LenschM, Wilkens L, JakobSM.  Effect of treatment delay on disease severity and needfor resuscitation in porcine fecal peritonitis. CriticalCare Med 2012; 40(10) 2841-9.  * Contributed equally

VudaM, D'Souza R, UpadhyaS, Kumar V, Rao N, Kumar V, Boillat C, Mungli P. Hepatoprotective andantioxidant activity of aqueous extract of Hybanthus enneaspermus againstCCl4-induced liver injury in rats. ExpToxicol Pathol. 2011 Apr 6. [Epub ahead of print].

Vuda M,Brander L, Schröder R, Jakob SM, Takala J, Djafarzadeh S. Effects ofcatecholamines on hepatic and skeletal muscle mitochondrial respiration afterprolonged exposure to fecal peritonitis in pigs. InnateImmun.2012;18(2):217-30.

Djafarzadeh S, VudaM, Takala J, Ochs M, Jakob SM. Toll-like receptor-3-induced mitochondrialdysfunction in cultured human hepatocytes. Mitochondrion.2011; 11(1):83-8.

Regueira T, LepperPM, Brandt S, Ochs M, Vuda M, Takala J, Jakob SM, Djafarzadeh S. HIF-1α induction by tumour necrosis factor-a, but not toll-like receptor agonists, modulatescellular respiration in culture human hepatocytes. Liver Int. 2009; 29(10):1582-92.

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