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  Dr. KARTICK PRAMANIK  
 
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Title : Dr.
First Name : KARTICK
Last Name : PRAMANIK
University/Institution : Penn State University
Phone # : 8063162737
Email ID : kartickpramanik@gmail.com
City : State College
Country : United States
State : Pennsylvania
Zipcode : 16803
Department : Vaterinary and Biomedical Sciences
Company Name :
Area of Research
Carcinogenesis and Toxicology
Area of Expertise
Cancer Biology and Toxicology
Brief Description of Research Interest :
Thioredoxin (Trx) is a cellular redox enzyme that plays an essential role in regulation of cell growth, apoptosis, and activation. There are two isoform of Trx in mammalian cells known as cytosolic and mitochondrial Trx (Trx1 and Trx2, respectively). Trx1 and Trx2 are encoded by distinct nuclear genes and Trx2 contains a mitochondrial targeting signal peptide. The mitochondrion is the major source of ROS generated during physiological respiration and pathological condition in response to cytokines. Therefore, the mitochondrial antioxidant systems including Trx2, Trx2 reductase, mitochondrial Trx peroxidase, and manganese superoxide dismutase (MnSOD) are critical in regulating mitochondrial ROS-induced cytotoxicity. Up-regulation of Trx has been shown in several kind of human cancer. My initial study has shown that that capsaicin-induced apoptosis in pancreatic cancer cells was associated with the generation of ROS in early time point and persistent disruption of mitochondrial membrane potential and. Furthermore, we examined the mechanism by which capsaicin-mediated oxidative stress inhibits Trx and activates ASK1, leading to apoptosis in pancreatic cancer cells in vitro and in vivo. However, it has not been shown that role of mitochondrial Trx-2/ASK1 complex on Oxidative stress in respect of cancer prevention in cancer cells. Therefore, our hypothesis is that capsaicin mediated oxidative stress inhibits mitochondrial Trx-2/ASK1 complex activate ASK1/JNK pathway resulted induction of apoptosis in mammalian cancer cells. We will prove this hypothesis by using specific Trx and ASK1 inhibitor and activator in the mitochondrial fraction.
Representative Publications :

Research Papers

1.    Pramanik KC,Pandey AK (2013) Natural Compounds: Prospective of Chemoprevention. EndocrinolMetab Synd 2: e115. doi:10.4172/2161-1017.1000e115

2.        Pramanik KC,Pandey AK (2013) Critical Role of Oxidant and Anti-oxidant in Cancer. MolecularBiology 2: e110. doi:10.4172/2168-9547.1000e110

3.        Kartick C Pramanik, Shashi Kudugunti,Neel Fofaria, Majid Moridani, Sanjay K. Srivastava.  Caffeic acid phenethyl ester suppressesmelanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis 2013 Sep;34(9):2061-70

4.      Reilly CA, Henion F, BugniTS, Ethirajan M, Stockmann C, Pramanik KC, Srivastava SK, Yost GS Reactive Intermediates Produced from theMetabolism of the Vanilloid Ring of Capsaicinoids by P450 Enzymes. Chem Res Toxicol. 2013, 26, 55−66

5.        Kartick C.Pramanik, Sanjay K. Srivastava. Apoptosis signal regulating kinase 1-Trxcomplex dissociation by capsaicin causes pancreatic tumor growth suppression byinducing apoptosis. Antioxid Redox Signal (ARS). 2012 Nov 15;17(10):1417-32.

6.   Kartick C.Pramanik, Srinivas Reddy Boreddy, SanjayK. Srivastava. Role of mitochondrial electron transport chain complexes incapsaicin mediated oxidative stress leading to apoptosis in pancreatic cancercells. PLoS One. 2011; 6(5):e20151, 1-16.

7. Srinivas Reddy Boreddy, Kartick C. Pramanik, Sanjay K. Srivastava. Pancreatic tumorsuppression by benzyl isothiocyanate is associated with inhibition ofPI3K/AKT/FOXO pathway. Clinical Cancer Research. 2011; 17(7):1784-1795.

8.  Kartick C Pramanik, Stephen E. Wrightand Sanjay K. Srivastava. Multiple Targets of Capsaicin in Cancer. IndianJournal of Biochemistry and Biophysices (IJBB) Review, 2013

9.  Kartick C.Pramanik, Sanjay K. Srivastava. FOXO-1acetylation by capsaicin causes apoptosis in pancreatic cancer cells bytargeting SirT-1. Molecular Cancer Therapeutics (MCT) in revision.

10.   Kartick C. Pramanik, Sanjay K.Srivastava. Capsaicin Inhibits β-Catenin/TCF-1 Signaling by disrupting nuclearβ-Catenin/TCF-1 Complex: Critical Role of STAT-3. In review.

11.  Kartick C. Pramanik, T. K. Chatterjee. PITC-2 Encapsulated intoLiposome Enhance Antipoliferative Effect on Cancer cell line (K562, U937, HL60)in vitro. International J. Biomedical and pharmaceutical Sciences (IJBPS)2010, 4(1&2): 54-60.

12.      Biswajit Ruhidas, KartickChandra Pramanik, Rajat Ray, Tapas Pal, Biswanath Sa, Tapan KumarChatterjee. Pharmacological Activities of Diclofenac Sodium-Loaded Microspheres(DSMSs) in Rats. International J. Biomedical and pharmaceutical Sciences(IJBPS) 2010, 4(1&2): 48-53.

13. D. Midya, K. C.Pramanik, T. K. Chatterjee.Effect of AndrographolideEncapsulated Liposomal Formulation on Hepatic Damage and Oxidative Stress. International J. Biomedical andpharmaceutical Sciences (IJBPS). 2009, 3(1):55-59

14.  K. C. Pramanik, T. K. Chatterjee. Isolation,Characterization and Sub-acute Toxicity Studies of the New Compound PITC-2 Isolated from Tissue-CulturedMedicinal Plant  Pluchea indica (L.) Less. International J. Biomedical andpharmaceutical Science (IJBPS), 2009, 3(1):50-54

15.  T. Balasubramanian, Kartick Pramanik, and Tapan Kumar Chatterjee. Diuretic effect ofethanol extract of Stereospermum Suaveolens.Pharmacologyonline. 2009, 2: 625-635.

16.    S. Ghosh, K.C. Pramanik, T. K. Chatterjee. invitro Anti-oxidant Activities of Methanolic Root Extract of Tissue CulturedPluchea indica. PharmacognosyMagazine. 2008, 16(4), 174-181.

17.   K. C. Pramanik, T. K. Chatterjee. In vitro and in vivo antibacterial activities of root extract of tissue culturedPluchea indica (L.) Less. OrientalPharmacy of Experimental Medicine. 2008, 8(3), 295-301.

18.    K. C. Pramanik, T. K. Chatterjee. In vitroand in vivo antibacterial activitiesof root extract of tissue cultured Plucheaindica (L.) Less against bacillary dysentery. Pharmacognosy  magazine,2008, 14(4), 78-84

19.   K. C. Pramanik,T. K. Chatterjee. Wound healing properties of Tissue-Cultured Puchea indica(L.) Less root extract inrats. International J. Biomedical and pharmaceutical Sciences. 2008, 2(2):112-116.

20.  K. C. Pramanik,T. K. Chatterjee. Antitumor Activity and Anti-oxidant Role of Tissue cultured Pluchea indica against Ehrlich Ascitescarcinoma in Swiss Albino Mice. International journal of Biomedical andpharmaceutical Sciences. 2008, 2 (1),47- 50.

21.     M. Mishra, K. C. Pramanik, T. K. Chatterjee.Evaluation of anti-inflammatory, antipyretic & analgesic properties of Biophytum sensitivum (L.) DC. IndianDrugs. 2008, 45(2), 123-131.

22.    M. Mishra, D.Bondyopadhyay, K. C. Pramanik, T. K. Chatterjee. Antihyperglycemic activity of Biophytum sensitivum (L.) DC. inalloxan diabetic rats. Oriental Pharmacy and Experimental Medicine. 2007,7(4), 418-425

23.    R. Biswas, P.K. Dutta, B. Achari, D. Bondyopadhyay, M. Mishra, K. C. Pramanik,T. K. Chatterjee. Isolation of purecompound R/J/3 from Pluchea  indica (L.) Less. and its anti-amoebicactivities against Entamoeba histolytica.Phytomedicine. 2007, (14),534-537

24.      K. C. Pramanik, R.Biswas, D. Bandyopadhyay, M. Mishra, and T. K.Chatterjee. Evaluation of anti-ulcer properties of theleaf extracts of Juniperus communis L. in animals. Journal of Natural remedy. 2007, 7(2),207-213

25.     K. C. Pramanik,R. Biswas, A. Mitra, D. Bandyopadhyay, M. Mishra, and T. K.Chatterjee. Tissue culture of the plant Plucheaindica (L.) Less. andEvaluation of Diuretic Potential of its Leaves. Oriental Pharmacy and Experimental Medicine.2007, 7(2), 197-204

26.   K. C. Pramanik,P. Bhattacharya, R. Biswas, D. Bandyopadhyay, M. Mishra, and T. K. Chatterjee. Hypoglycemic and antihyperglycemic activityof leaf extract of Pluchea indica Less. Oriental Pharmacy and Experimental Medicine. 2006, 6(3), 232-236

27.  K. C. Pramanik, P. Bhattacharya, T. K. Chatterjee. S. C.Mondal. Anti-inflammatory activity of Methanol Extract of Albizzia lebbeck (Mimosaceae) Bark. European Bulletin of DrugResearch. 2005, Volume 13, 71-75

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