My research for the past six years has been focused on the understanding of the process of sarcomagenesis in the smooth muscle. I generated several mouse models that recapitulate the human disease and studied the molecular alterations that drive tumorigenesis. For this, much of my interest has focused on the characterization of mesenchymal stem cells derived from the bone marrow. Currently I am studying the biology of osteosarcoma. My main goal is to understand the biology of tumor-initiating cells in an effort to develop targeted therapies for complex karyotype sarcomas.

1.    Segura MF, Fontanals-Cirera B, Gaziel-Sovran A, Guijarro MV, Hanniford D, Zhang G, González-Gomez P, Morante M, Jubierre L, Zhang W, Darvishian F, Ohlmeyer M, Osman I, Zhou MM, Hernando E.BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy. Cancer Res. 2013 Oct 15;73(20):6264-76.

2.    Guijarro MV, Dahiya S, Danielson L, Vales-Lara FM, Menendez S, Segura MF, Popiolek D, Mittal K, Wei JJ, Pandolfi PP, Cordon-Cardo C, and Hernando E. Dual Pten/p53 suppression promotes sarcoma progression by triggering Notch signaling. Am J Pathol. 2013 Jun;182(6):2015-27.

3.    Danielson LS, Park DS, Rotllan N, Chamorro-Jorganes A, Guijarro MV, Fernandez-Hernando C, Fishman GI, Phoon CK, Hernando E. Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis. FASEB J. 2013 Apr;27(4):1460-7.

4.    Jeong YT, Cermak L, Guijarro MV, Hernando E, Pagano M. FBH1 protects melanocytes from transformation and is deregulated in melanomas. Cell Cycle. 2013 Apr 1;12(7):1128-32.

5.    Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K , Wienands K, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PCW, Antonescu CR, Rubin B, Schulz-Schaeffer W, Aberger F, Van den Brink G, Hahn H. Mutant Patched1 induces GIST-like tumors in Pdgfralpha+Kit- precursor cells in mice. Gastroenterology. 2013 Jan;144(1):134-144. 

6.    Guijarro MV, Vergel M, Marin JJ, Muñoz-Galván S, Ferrer I, Cajal SR, Roncador G, Blanco-Aparicio C, Carnero A. p38α limits the contribution of MAP17 to cancer progression in breast tumors. Oncogene. 2012 Oct 11;31(41):4447-59.

7.    Danielson LS, Menendez S, Stephan-Otto Attolini C, Guijarro MV, Bisogna M, Wei J, Socci ND, Levine DA, Michor F, Hernando E. A Differentiation-Based MicroRNA Signature Identifies Leiomyosarcoma as a Mesenchymal Stem Cell-Related Malignancy. Am J Pathol. 2010 Jun 17. Am J Pathol. 2010 Aug;177(2):908-17.

8.    Acosta JC, O’Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d’Adda di Fagagna F, Bernard D, Hernando E and Gil J. Chemokine Signaling via the CXCR2 Receptor reinforces Senescence. Cell. 2008 Jun 13;133(6):1006-18.

9.    Castro ME, Ferrer I, Cascón A, Guijarro MV, Lleonart M, Ramon y Cajal S, Leal JFM., Robledo M and Carnero A. PPP1CA contributes to the senescence program induced by oncogenic Ras. Carcinogenesis. 2008 29(3):491-9.

10.Leal JF, Fominaya J, Cascon A, Guijarro MV, Blanco-Aparicio C, Lleonart M, Castro ME, Ramon Y Cajal S, Robledo M, Beach DH, Carnero A. Cellular senescence bypass screen identifies new putative tumor suppressor genes. Oncogene. 2008 27(14):1961-70.

11.Guijarro MV, Link W, Rosado A, Leal JF, Carnero A. MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation. Carcinogenesis. 2007 Dec;28(12):2443-50.

12.Guijarro MV, Leal JF, Blanco-Aparicio C, Alonso S, Fominaya J, Lleonart M, Castellvi J, Ramon Y Cajal S, Carnero A. MAP17 enhances the malignant behaviour of tumor cells through ROS increase. Carcinogenesis. 2007 Oct;28(10):2096-104.

13.Guijarro MV, Leal JF, Fominaya J, Blanco-Aparicio C, Alonso S, Lleonart M, Castellvi J, Ruiz L, Ramon Y Cajal S, Carnero A. MAP17 overexpression is a common characteristic of carcinomas. Carcinogenesis. 2007 Aug; 28(8):1646-52.

14.Guijarro MV, Castro María E, Romero L, Moneo V, Carnero A. Large scale genetic screen identifies MAP17 as protein bypassing TNF-induced growth arrest. J Cell Biochem. 2007 May 1;101(1):112-21.

15.Castro María E, Guijarro MV, Moneo V, Carnero A. Cellular senescence induced by p53-ras cooperation in independent of p21waf1. J Cell Biochem 2004, 92: 514-524.

16.Carnero A, Blanco C, Blanco F, Castro ME., Guijarro MV., Fominaya J, Link W, Martínez JF., Moneo V, Renner O, Romero L and Rosado A. Exploring cellular senescence as a tumor suppressor mechanism. Rev Oncol 2003; 5(5):249-65.

17.Carnero A, Link W, Leal JFM, Renner O, Castro ME, Blanco F, Blanco C, Fominaya J, Moneo V, Guijarro MV, Romero L. Cellular senescence and cancer. Res. Adv. in Cancer 2003, 3: 183-198.

18.Moneo V, Guijarro MV, Link W, Carnero A. Overexpression of cyclin D1 inhibits TNF-induced growth arrest. Journal of Cellular biochemistry 2003, 89 (3): 484-499.

19.Guijarro MV, Indart A, Aruoma OI, Viana M, Bonet B. Effects of ergothioneine on diabetic embryopathy in pregnant rats. Food Chem Toxicol 2002, 40 (12): 1751-5.