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  Dr. NICOLAS SZABO FRESNAIS  
 
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Title : Dr.
First Name : NICOLAS
Last Name : SZABO FRESNAIS
University/Institution : University of Utah
Email ID : nicolas.szabo@hsc.utah.edu
City : Salt Lake City
Country : United States
State : Utah
Zipcode : 84103
Department : biochemistry
Company Name :
Area of Research
Cell signaling, biochemistry.
Area of Expertise
cardiology
Brief Description of Research Interest :
I worked on the Interleukin 6 (IL-6) gene regulation in thyroid cells and on the effect of IL-6 in cardiac cells during my PhD. As a postdoc in biochemistry, my research has focused on protein-protein interactions regulated by phosphorylation. I am currently involved in a research project that focuses on D-peptide inhibitors for viral entries.

Representative Publications :
1. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19778-83. doi:
10.1073/pnas.1305427110. Epub 2013 Nov 18.
Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms.
Vandeput F, Szabo-Fresnais N, Ahmad F, Kho C, Lee A, Krall J, Dunlop A, Hazel
MW, Wohlschlegel JA, Hajjar RJ, Houslay MD, Manganiello VC, Movsesian MA.

2. Cell Signal. 2010 Jul;22(7):1143-52. doi: 10.1016/j.cellsig.2010.03.009. Epub
2010 Mar 11.
A new regulation of IL-6 production in adult cardiomyocytes by beta-adrenergic
and IL-1 beta receptors and induction of cellular hypertrophy by IL-6
trans-signalling.
Szabo-Fresnais N, Lefebvre F, Germain A, Fischmeister R, Pomérance M.



3. Mol Cell Endocrinol. 2008 Mar 12;284(1-2):28-37. doi: 10.1016/j.mce.2007.12.017.
Epub 2008 Jan 8.
Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene
expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors.
Szabo-Fresnais N, Blondeau JP, Pomérance M.


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