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  Dr. IULIANA ENE  
 
Address 1 :
Address 2 :
Title : Dr.
First Name : IULIANA
Last Name : ENE
University/Institution : Brown University
Phone # : 401-573-4677
Email ID : iuliana_ene@brown.edu
City : Providence
Country : United States
State : Rhode island
Zipcode : 02912
Department : Molecular Microbiology and Immunology
Company Name :
Area of Research
Microbiology/Molecular Biology
Area of Expertise
fungal biology, metabolism, sex and mating, Candida species
Brief Description of Research Interest :

My research interests focus on the ability of fungi to adapt to diverse and hostile environments, ability at which the human pathogen Candida albicans excels.  My interest in this organism has been stimulated by its enormous versatility.  It is parasitic in nature, it can colonize and infect virtually any tissue it encounters, it carries an arsenal of defences and invasion strategies well suited for every niche it inhabits, while having a remarkable ability to tolerate aneuploidies and chromosomal rearrangements.

My current research is focused on the ways in which the mammalian host environment drives genetic and phenotypic diversity in this fungal pathogen.  My long-term goals are to understand how virulence traits evolve under host selective pressure and how the molecular mechanisms mediating these traits can be tackled to address current therapeutic needs.
Representative Publications :

Ene, I. V., Brunke S., Brown, A. J., Hube, B., Metabolism in fungal pathogenesis, Cold Spring Harbor Perspectives, 2015 (book chapter, in press).

Ene, I. V., Bennett, R. J., The cryptic sexual strategies of human fungal pathogens, Nature Reviews Microbiology, 2014, 12:239-251.

Ene, I. V., Brown, A. J., Integration of metabolism with virulence in Candida albicans, book chapter in Mycota XIII, Fungal Genomics, Nowrousian, M. (Ed.), Springer 2014 (book chapter).

Brown, A.J.P., Budge, S., Kaloriti, D., Tillmann, A., Jacobsen, M.D., Yin, Z., Ene, I.V., Bohovych, I.M., Sandai, D., Kastora, S., Potrykus, J., Ballou, E.R, Childers, D.S., Shahana, S., Leach, M.D., Stress adaptation in a pathogenic fungus.  J Exp Biol. 2014, 217:144-55.

Ene, I. V., Cheng, S. C., Netea, M. G., Brown, A. J., Growth of Candida albicans cells on the physiologically relevant carbon source, lactate, affects their recognition and phagocytosis by immune cells. Infection and Immunity. 2013, 81: 238-248. Highlighted on the journal cover, Infection and Immunity, Jan 2013

Sandai, D., Yin, Z., Selway, L., Stead, D., Walker, J., Leach, M. D., Bohovych I. M., Ene, I. V., Budge, S., Odds, F. C., Gow, N. A., Brown, A. J., The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast, Candida albicans. MBio 2012, 3(6):e00495-12.

Ene, I. V., Heilmann, C. J., Sorgo, A. G., Walker, L. A., de Koster, C. G., Munro, C. A., Klis, F. M., Brown, A. J., Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans. Proteomics 2012, 12:3164-79. Paper spotlighted on the cover of the journal, Proteomics, Nov 2012

Ene, I. V., Adya, A. K., Wehmeier, S., Brand, A. C., MacCallum, D. M., Gow, N. A., Brown, A. J., Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. Cell. Microbiol. 2012, 14, 1319-1335.Selected as Editor’s Choice, Cellular Microbiology, Sept. 2012

Ene, I. V., Bennett, R. J., Hwp1 and related adhesins contribute to both mating and biofilm formation in Candida albicans. Euk. Cell. 2009, 8, 1909-1913.

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