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Dr. APARNA RAO
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Address 1
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Address 2
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Title
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Dr.
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First Name
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APARNA
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Last Name
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RAO
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University/Institution
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University of Pittsburgh
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Email ID
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aparna.vrao@gmail.com
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City
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Pittsburgh
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Country
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United States
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State
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Pennsylvania
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Zipcode
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15217
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Company Name
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Area of Research
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Tumor Immunology, transplant research
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Brief Description of Research Interest :
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Transplant recipients typically are put on a life-long immunosuppressive regimen that inturn, can induce various adverse reactions. Therefore, there is a need todevelop a therapeutic intervention that maximizes transplant acceptance withminimum immunosuppression. Thymus transplant under the kidney capsule has beena well-documented approach to induce transplant tolerance in rodent as well aslarge animal models. Such efforts primarily require thymectomy of the native thymusin order to avert untoward adverse reactions. These studies are crucial due to the implications ofthe potential of the thymus in mediating long-term allograft acceptance. However,the underlying mechanisms of transplant acceptance have been poorly studied. We hypothesize that transplanting the thymus in a highly vascularized, ‘rich’environment like the lymph node allows for effective cross-talk between theectopic and the native thymus, leading to seamless incorporation of the ectopicthymus and the subsequent allograft.
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Representative Publications :
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Shock block for improved immunotherapy.
Rao A, Lowe DB, Storkus WJ.
Oncoimmunology. 2012 Nov 1;1(8):1427-1429. - PMID: 23243617
Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells.
Rao A, Taylor JL, Chi-Sabins N, Kawabe M, Gooding WE, Storkus WJ.
Cancer Res. 2012 Jul 1;72(13):3196-206. doi: 10.1158/0008-5472.CAN-12-0538. Epub 2012 May 2. Erratum in: Cancer Res. 2012 Oct 15;72(20):5431.
Combined vaccine+axitinib therapy yields superior antitumor efficacy in a murine melanoma model.
Bose A, Lowe DB, Rao A, Storkus WJ.
Melanoma Res. 2012 Jun;22(3):236-43. doi: 10.1097/CMR.0b013e3283538293.
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Resume
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