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Dr. SA CHAK
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Address 1
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Address 2
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Title
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Dr.
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First Name
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SA
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Last Name
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CHAK
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University/Institution
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Stony Brook Medicine
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Phone #
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857-333-3454
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Email ID
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saikat75c@yahoo.com
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City
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Stony Brook
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Country
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United States
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State
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New york
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Zipcode
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11794
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Department
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Anesthesiology
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Company Name
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Area of Research
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Modulation of TRPV1 and Voltage gated Sodium Channels in DRG neuron and interneuron of spinal cord.
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Area of Expertise
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Ion Channel Pharmacology, Patch clamp, Molecular biology, Cloning, Protein Purification, Confocal Microscopy, Microbiology
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Brief Description of Research Interest :
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My interest lies in the exact molecular mechanism of herbal compounds on the modulation of voltage-gated sodium channels and TRPV1 channels expressed in Dorsal Root Ganglia (DRG) neurons and interneurons in the spinal cord. My long termgoals as an investigator is to elucidate such facts by electrophysiological (patchclamp), behavioral, and biochemical approach.
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Representative Publications :
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Nikolett T. Nagy, Saikat Chakraborty, GáborM. Harami, James R. Sellers,Takeshi
Sakamoto,and Mihály Kovács. (2013). A Subdomain Interaction atthe Base of the Lever Allosterically Tunes theMechanochemical Mechanism of Myosin 5a. PLoS One.8(5):e62640.
- Ketrija Touw, Saikat Chakraborty, Wenwu Zhang, Alexander G.Obukhov, Jonathan D. Tune, Susan J. Gunst, B. Paul Herring. (2012) Type1 diabetes leads to altered calcium signalling in chronic and acute diabetic mice. American journal of Physiology-Gastrointestinal and Liver Physiology 302(1):G66-76.
- Saikat Chakraborty, Berwick ZC, Bartlett PJ, Kumar S, Thomas AP, Sturek MS, Tune JD, Obukhov AG. (2011) Bromoenol lactone (BEL) inhibits CaV1.2 and TRPC Channels. Journal of Pharmacology and Experimental Therapeutics. 339, 329-40. [Cover Page]
- Kumar S, Saikat Chakraborty, Barbosa C, Brustovetsky T, Brustovetsky N, Obukhov AG. (2011) Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: The role of TRPC channels. Journal of Cell Physiology. 227(4):1408-19.
- Saikat Chakraborty, Makiko Sakka, Tetsuya Kimura, Kazuo Sakka. Cloning and Expression of a Clostridium kluyveri Gene Showing Diaphorase Activity. Journal of Bioscience, Biotechnology and Biochemistry.2008, 72 (3): 735-41.
- Saikat Chakraborty, Makiko Sakka, Tetsuya Kimura, Kazuo Sakka. Two Proteins with Diaphorase Activity from Clostridium thermocellum and Moorella thermoacitica. Journal of Bioscience, Biotechnology and Biochemistry.2008, 72 (3): 877-9.
- Saikat Chakraborty, Makiko Sakka, Tetsuya Kimura, Kazuo Sakka. Characterization of a Dihydrolipoyl Dehydrogenase Having Diaphorase Activity of Clostridium kluyveri. Journal of Bioscience, Biotechnology and Biochemistry.2008, 72(4):982-8.
- Sukhada Mohandas, Rawal R D, Manmohan M, Saikat Chakraborty , Manjula N R, Laxmikantha H C. “Interaction of Fusarium oxysporum fsp cubense with Pseudomonas fluorescens pre-colonized to Banana roots”– World Journal of Microbiology and Biotechnology, 2004, Vol. 20, no. 6, pp. 651-655(5).
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Resume
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