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  Dr. KECHUN YANG  
 
Address 1 :
Address 2 :
Title : Dr.
First Name : KECHUN
Last Name : YANG
University/Institution : University of Pennsylvania
Phone # : 2155731954
Email ID : yangkch2000@gmail.com
City : Philadelphia
Country : United States
State : Pennsylvania
Zipcode : 19104
Department : Neuroscience
Company Name :
Area of Research
Drug addition, learning & memory
Area of Expertise
Patch clamp, nicotinic receptors, dopamine, LTP
Brief Description of Research Interest :
My studies have always focused on: 1.physiological and pharmacological properties of nicotinic acetylcholine receptors (nAChRs) and the roles of these nAChRs in nicotine addiction by employing perforated-patch clamp recordings in single dissociated neurons and in brain slices; 2.  dopaminergic  regulation of spike-timing dependent plasticity  in the dentate gyrus.
Representative Publications :

1. Yang K*, ZhangJ, Wu J (2013) Nicotinic modulation of GABAA receptor function insingle dopaminergic neurons freshly-dissociated from rat substantia nigra parscompacta. Biochem & Pharmacol S1: 003.1.     (* Co-corresponding author)

2. Schmidt E,Lecavalier D, Wu C, Yang K, Wu J (2012) Dual effects of iptakalim onnicotine-induced rat behavioral sensitization. Pharmacologia 3: 506-512.

3. Yang K, BuhlmanL, Khan GM, Nichols RA, Jin G, et al. (2011) Functional Nicotinic AcetylcholineReceptors Containing {alpha}6 Subunits Are on GABAergic Neuronal BoutonsAdherent to Ventral Tegmental Area Dopamine Neurons. J Neurosci 31: 2537-2548.

4. Li G, Yang K,Zheng C, Liu Q, Chang Y, et al. (2011) Functional rundown of gamma-aminobutyricacid(A) receptors in human hypothalamic hamartomas. Ann Neurol 69: 664-672.

5. Jin Y, Yang K,Wang H, Wu J (2011) Exposure of nicotine to ventral tegmental area slicesinduces glutamatergic synaptic plasticity on dopamine neurons. Synapse 65:332-338.

6. Zheng C, YangK*, Liu Q, Wang MY, Shen J, et al. (2010) The Anticonvulsive Drug LamotrigineBlocks Neuronal {alpha}4{beta}2 Nicotinic Acetylcholine Receptors. J PharmacolExp Ther 335: 401-408.(*co-first author)

7. Wu C, Yang K*,Liu Q, Wakui M, Jin GZ, et al. (2010) Tetrahydroberberine blocks ATP-sensitivepotassium channels in dopamine neurons acutely-dissociated from rat substantianigra pars compacta. Neuropharmacology 59: 567-572.(*co-first author)

8. Gao M, Jin Y,Yang K, Zhang D, Lukas RJ, et al. (2010) Mechanisms involved in systemicnicotine-induced glutamatergic synaptic plasticity on dopamine neurons in theventral tegmental area. J Neurosci 30: 13814-13825.

9. Yang K, Hu J,Lucero L, Liu Q, Zheng C, et al. (2009) Distinctive nicotinic acetylcholinereceptor functional phenotypes of rat ventral tegmental area dopaminergicneurons. J Physiol 587: 345-361.

10. Xiao C, Yang KC*, Zhou CY, Jin GZ, Wu J, et al. (2009) Nicotine modulates GABAergictransmission to dopaminergic neurons in substantia nigra pars compacta. ActaPharmacol Sin 30: 851-858. (* co-first author)

11. Leonard BW,Mastroeni D, Grover A, Liu Q, Yang K, et al. (2009) Subventricular zone neuralprogenitors from rapid brain autopsies of elderly subjects with and without neurodegenerativedisease. J Comp Neurol 515: 269-294.

12. Wu J, DeChonJ, Xue F, Li G, Ellsworth K, Gao M, Liu Q, Yang K, et al. (2008) GABA(A) receptor-mediated excitationin dissociated neurons from human hypothalamic hamartomas. Exp Neurol 213:397-404.

13. Wang K, Zheng C, Wu C, Gao M, Liu Q, Yang K, et al. (2008) alpha-Chloralose diminishes gammaoscillations in rat hippocampal slices. Neurosci Lett 441: 66-71.

14. Wu J, Chang Y, Li G, Xue F, Dechon J, Ellsworth K, Liu Q, Yang K, et al. (2007) Electrophysiological Properties andSubunit Composition of GABAA Receptors in Patients With Gelastic Seizures andHypothalamic Hamartoma. J Neurophysiol 98: 5-15.

15. Wu J, Hu J,Chen YP, Takeo T, Suga S, Dechon J, Liu Q, Yang KC, et al. (2006) Iptakalim modulates ATP-sensitive K(+)channels in dopamine neurons from rat substantia nigra pars compacta. JPharmacol Exp Ther 319: 155-164.

16. Yang KC, Jin GZ, Wu J (2009) Mysterious alpha6-containing nAChRs: function, pharmacology,and pathophysiology. Acta Pharmacol Sin 30: 740-751.

17.Yang K, Jin G, Wu J (2007) The neuropharmacology of (-)-stepholidine and itspotential applications. Curr Neuropharmacol 5: 289-294.

18.Yang KC, Wang MY (2005) The study of the mechanisms underlying the effects of general anesthetics on spinal cord. Sheng Li Ke Xue Jin Zhan 36:13-17. 

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