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Dr. RAVI PATHAK
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Address 1
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Address 2
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Title
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Dr.
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First Name
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RAVI
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Last Name
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PATHAK
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University/Institution
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Baylor College Of Medicine
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Email ID
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ravi.pathak@bcm.edu
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City
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Houston
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Country
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United States
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State
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Texas
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Zipcode
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77030
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Department
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Otolaryngology
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Company Name
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Area of Research
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Cancer Biology
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Area of Expertise
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Systems Biology, Genomics, Proteomics, Molecular Biology
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Brief Description of Research Interest :
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My research focuses on a systems level understanding of cancer by integrating genomic, proteomic and structural informatics tools to unravel the feed-back and cross-regulatory signaling loops in different in-vitro and in-vivo models. By applying a "bench-bed" translational approach, I would want to drive novel drug discovery efforts to offer effective treatment therapies for cancer patients.
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Representative Publications :
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PEER- REVIEWED RESEARCH PUBLICATIONS
1. Uversky,V.,Davé, V., Iakoucheva,L.M., Malaney,P., Metallo,J.S., Pathak,R.R., Joerger, C.A. (2014). Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases (2014) Chem. Rev.114 (13), pp 6844–6879 DOI:10.1021/cr400713r. PMID 248030552.
2. Pathak, R.R. and Davé, V. Integrating Omics Technologies to StudyPulmonary Physiology and Pathology at the Systems Level (2014). Cell Physiol and Biochem 33 (5), 1239-1260, PMID 24802001.
3. Pathak, R.R., Grover, A., Malaney, P., Quarni, W.,Pandit, A., Gipson, DA., Davé, V. (2013) Loss of Tumor Suppressor PTEN Induces Leptin Mediated Leptin Gene Expression: A Feed-Forward Loop Operating in the Lung. J.Biol.Chem 288 (41), 29821-29835, PMC 3795281.
4. Pathak, R.R., Malaney, P., Xue, B., Uversky, V., Davé,V. (2013) Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility. Sci Rep. 2013;3:2035, PMC3687229.
5. Patel,J., Pathak R.R. and Mujtaba, S.(2011) The Biology of Lysine Acetylation Integrates Transcriptional Programming and Metabolism. Nutri Metabolism.8:12, PMC3060110.
6. Pathak, R.R. and Lochab, S. (2010) A method for rapidisolation of total RNA of high purity and yield from Arthrospira platensis. CanJ Microbiol. 56 (7), 578-584, PMID20651857.
7. Pathak, R.R., Das, S.K., Choudhury, D., and Raghuram,N. (2009) Genomewide bioinformatic analysis negates any specific role for Dof,GATA and Ag/cTCA motifs in nitrate responsive gene expression in Arabidopsis.Physiol Mol Biol Plants. 15 (2), 145-150, PMC3550365
8. Pathak, R.R., Ahmad, A., Lochab. S. and Raghuram, N.(2008) Molecular physiology of plant N-use efficiency and biotechnological optionsfor its enhancement. Current Science special issue on reactive nitrogen Curr.Sci. (00113891) 94 (11).
9. Das,S.K., Pathak, R.R., Choudhury, D.,and Raghuram, N. (2007) Genomewide computationalanalysis of nitrate response elements in rice and Arabidopsis. Mol. Genet.Genomics. 278 (5), 519-525, PMID17680272
BOOKS AND BOOK CHAPTERS
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1. Pathak, R.R. (2014) Metalloenzymes: Relevance in biological systems and potentialapplications. In Metalloneutraceuticals (In press).
2. Patel, J., PathakR.R. and Mujtaba, S. (2013) Lysine Acetylation in TranscriptionalProgramming and Metabolism. In Epigenetics and Pathology. Kasirajan Ayyanathan(Eds),Apple Academic Press, USA.
3. Pathak, R.R., Lochab, S., Raghuram, N. (2011) Improving nitrogen use efficiency. In ComprehensiveBiotechnology , 2nd Edition, Vol. 4, pp.209-218, Elsevier, Oxford
4. Pathak,R.R. and Nandula Raghuram (2010)Annual Review of Plant Biology, Merchant, Briggs and Chandler(eds.) Book Review, Curr. Sci.
5. Pathak, R.R. (2007) Introduction to Biotechnology - Atlantic Publishers (Book, ISBNno: 81-269-0598-0).
6. Pathak,R.R. and Nandula Raghuram (2007)Annual Review of Plant Biology, Merchant, Briggs and Chandler(eds.) Book Review, Curr. Sci.
7. Lochab, S., Pathak, R.R. and Raghuram, N. (2007) Molecular approaches for enhancement ofnitrogen use efficiency in plants. In Agricultural N use - EnvironmentalConcerns, Y.P. Abrol, N. Raghuram and M.S. Sachdev (Eds). IK International,Delhi. Pp. 327-350.
8. Raghuram, N., Pathak R.R. and Sharma, P. (2006)Signaling and the molecular aspects of N-use efficiency in higher plants. InBiotechnological approaches to improve nitrogen use efficiency in plants, R.P.Singh and P.K. Jaiwal (Eds). Studium Press LLC. Houston, Texas, USA. Pp. 19-40.
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