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    ISSN : 2328-9791
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  Dr. MARILENA TAURO  
 
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Title : Dr.
First Name : MARILENA
Last Name : TAURO
University/Institution : Moffitt Cancer Center and Research Institute
Phone # : 813-419-9341
Email ID : marilena.tauro@moffitt.org
City : Tampa
Country : United States
State : Florida
Zipcode : 33612
Department : Tumor Biology
Company Name :
Area of Research
Bone Metastases
Area of Expertise
Chemical strategies for Bone Targeting
Brief Description of Research Interest :
My current focus is testing the role of bone seeking matrix metallo proteinase inhibitors (BMMPIs) on the treatment and cure of breast to bone metastases.  During my PhD in Pharmaceutical Chemistry in the lab of Dr. Paolo Tortorella at the University of Bari, Italy, I synthesized multiple series of small molecules as inhibitors of different enzymes known to play roles in the tumor microenvironment, such as MMPs and carbonic anhydrase isoforms. These syntheses involved preliminary docking calculation studies that predicted the successful chemical structure features of optimized enzyme inhibitors and their subsequent synthesis. Compounds with high purity were obtained in grams quantity thanks to optimization of the synthetic and analytic techniques such as HPLC, LC/MS-GC/MS and NMR.  In September of 2013 I started my post doctoral fellowship in the Lynch Lab, and currently I am focused in testing the efficacy of highly specific bone seeking MMP-2inhibitors in mouse models of breast to bone metastasis. I have extensive experience in the invitro and in vivo techniques,histology and imaging modalities (microCT, microSPECT, Faxitron-Xray).

Representative Publications :

Tauro M, Laghezza A, Loiodice F, Agamennone M, Campestre C, Tortorella P. Arylaminomethylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors. Bioorganic & medicinal chemistry. 2013; 21(21): 6456-65.

Tauro M, Loiodice F, Ceruso M, Supuran CT, Tortorella P. Arylaminobisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII. Bioorganic & medicinal chemistry letters. 2014;24(8): 1941-3.

Tauro M, Loiodice F, Ceruso M, Supuran CT, Tortorella P. Dual carbonicanhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acidmoieties targeting bone tumors. Bioorg Med Chem Lett. 2014; 24(12): 2617-20.

Tauro M, McGuire J, Lynch CC. New approaches to selectively target cancer associated matrix metalloproteinase activity. Cancer & MetastasisReviews Cancer Metastasis Rev., 2014 Oct 18.

Campestre C, Agamennone M, Tauro M, Tortorella P, Phosphonate Emerging Zinc Binding Group inMatrix Metalloproteinase Inhibitors. Current Drug Targets, in press.

Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F; Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175; Eur J Med Chem. 2014 Nov 24;90C:583-594.

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