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Dr. SARA GOMBASH LAMPE
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Address 1
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Address 2
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Title
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Dr.
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First Name
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SARA
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Last Name
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GOMBASH LAMPE
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University/Institution
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Ohio State University
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Email ID
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sara.gombashlampe@osumc.edu
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City
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Columbus
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Country
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United States
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State
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Ohio
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Zipcode
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43210
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Department
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Neuroscience
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Company Name
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Area of Research
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Neuroscience, Neurogastroenterology, Gene Therapy
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Area of Expertise
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Neurogastroenterology, Neuromuscular Disease, Neurodegnerative Disease, Aging
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Brief Description of Research Interest :
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I am currently investigating defects in neuromuscular transmission from the enteric nervous system to smooth muscle of the gastrointestinal tract in the context of neuromuscular disease. Using transgenic mice, I have characterized novel models of the neuromuscular disease Spinal Muscular Atrophy, and am using the gastrointestinal system of these mice to study gastrointestinal dysfunction in the disease and as an ex vivo model of neurodegeneration that may be used to develop novel therapeutics. I am also developing methods of gene delivery via gene therapy to enteric neurons and glial cells as novel method of therapeutic gene delivery to the gut. I am investigating gene therapy to the gastrointestinal system as a novel therapeutic for both neuromuscular disease patients and for those suffering from functional gastrointestinal disorders. My previous training involved gene therapy for Parkinson's disease and gene therapy in aging animal models.
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Representative Publications :
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Gombash, S.E., Cowley, CJ., Fitzgerald, J.A., Hall, J.D., Mueller, C., Christofi, F.L., Foust, K.D. (2014). Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice. Frontiers in Molecular Neuroscience, 7:81. PMID 25360081
Polinski, N.K., Gombash, S.E., Kemp, C.J., Kuhn, N.C., Cole-Strauss, A., Wohlgenant, S.L., Kanaan, N.M., Steece-Collier, K., Lipton, J.W., Manfredsson, F.P., Sortwell, C.E. (2014). Recombinant adeno-associated virus type 2/5-mediated gene transfer is reduced in the aged rat brain. Neurobiology of Aging, in press. PMID: 25457558
Gombash, S.E., Manfredsson, F.P., Mandel, R.J., Collier, T.J., Fischer, D.L., Kemp, C.J., Kuhn, N.M, Wohlgenant, S.L., Fleming, S.M., Sortwell, C.E. (2014). Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared to overexpression in both the striatonigral and nigrostriatal pathway. Gene Therapy, 21(7): 682-93. PMID 24807806
Gombash Lampe, S.E., Kaspar, B.K, Foust, K.D. (2014). Intravenous injection in neonatal mice. Journal of Visual Experiments, (93), e52037, doi: 10.3791/52037
Gombash, S.E., Manfredsson, F.P., Kemp, C.J., Kuhn, N.C., Fleming, S.M., Egan, A.E., Grant, L.M., Ciucci, M.R., MacKeigan, J.P., Sortwell, C.E. (2013). Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System. PLoS One, 8(11):e84126. PMID 24312298
Gombash, S.E., Lipton, J.W., Collier, T.J., Madhavan, L., Steece-Collier, K., Cole-Strauss, A., Terpstra, B.T., Spieles-Engemann, A.L., Daley, B.F., Wohlgenant, S.L., Thompson, V.B., Mandel, R.J., Sortwell, C.E. (2011). Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular Therapy, 20(3): 544-554. PMID 22008908
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Resume
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