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  Dr. SUPRIYA KULKARNI  
 
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Title : Dr.
First Name : SUPRIYA
Last Name : KULKARNI
University/Institution : Yale University School of Medicine
Email ID : supriya.kulkarni@yale.edu
City : New Haven
Country : United States
State : Connecticut
Zipcode : 06511
Department : Digestive Diseases, Liver Center
Company Name :
Area of Research
Liver Biology, Hepatobiliary transport, enteroendocrine signaling
Area of Expertise
Steatosis, cholestasis, adipogenesis
Brief Description of Research Interest :
In a broad sense, my research interests include identifying novel therapeutic targets for metabolic liver diseases such as steatosis and cholestasis. My research focuses on determining mechanisms by which liver injury can be alleviated and function improved in surgically, genetically and diet induced murine models of metabolic liver diseases.  I have also worked on liver membrane transporters important in disposition of endo- and xenobiotics.  Currently, I am pursuing novel intestine derived signaling pathways that can alleviate adiposity and steatosis and identifying novel therapeutics in reversing cholestatic liver injury.

Representative Publications :
Selected Publications:
1. Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human.

Kulkarni SR, Donepudi AC, Xu J, Wei W, Cheng QC, Driscoll MV, Johnson DA, Johnson JA, Li X, SlittAL.

Antioxid Redox Signal. 2014 Jan 1;20(1):15-30. doi: 10.1089/ars.2012.5082.



2.  
Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

Xu J, Kulkarni SR, Donepudi AC, More VR, Slitt AL.

Diabetes. 2012 Dec;61(12):3208-18. doi: 10.2337/db11-1716. 



3.  Effect of caloric restriction and AMPK activation on hepatic nuclear receptor, biotransformation enzyme, and transporter expression in lean and obese mice.

Kulkarni SR, Xu J, Donepudi AC, Wei W, Slitt AL.

Pharm Res. 2013 Sep;30(9):2232-47. doi: 10.1007/s11095-013-1140-2013-1140-2



4.  UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.

Xu J, Kulkarni SR, Li L, Slitt AL.

Drug Metab Dispos. 2012 Feb;40(2):259-66. doi: 10.1124/dmd.111.039925.


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