log  
logo
A Journal of Postdoctoral Research.
 
     Login   |   Register   
    ISSN : 2328-9791
left right
 
 
Hall of Fame
EDITORIAL BOARD
btm
 
top
  Dr. HASHEM DBOUK  
 
Address 1 :
Address 2 :
Title : Dr.
First Name : HASHEM
Last Name : DBOUK
University/Institution : UT Southwestern MC
Email ID : hashem.dbouk@utsouthwestern.edu
City : Dallas
Country : United States
State : Texas
Zipcode : 75390
Department : Pharmacology
Company Name :
Area of Research
Kinases in endothelial functions
Area of Expertise
kinase structure-function analysis
Brief Description of Research Interest :

My general research interests are protein structure-function analysis, identifying interaction and signaling networks of kinases, and the role of different kinases in endothelial cell functions.

Representative Publications :

Dbouk, HA, Weil, LM, Perera, GKS, Dellinger, MT, Pearson, G, Brekken, RA,and Cobb, MH. Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proceedings of the National Academy of Sciences USA 2014; 111(45): 15999-16004. 

 Vadas, O, DboukHA*, Shymanets, A*, Perisic, O, Burke JE, Abi Saab, WF, Khalil, BD, Harteneck, C,Bresnick, AR, Nurnberg, B, Backer, JM, and Williams, RL. Molecular determinants of PI3Kγ-mediated activation downstream of GPCRs. Proceedings of the National Academy of Sciences USA 2013 Nov 19; 110(47): 18862-18867.

Dbouk, HA, Khalil, BD, Wu, H, Shymanets, A, Nürnberg,B, and Backer, JM. Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase. PLoS One 2013 May; 8(5):e63833.

Dou, Z, Pan, JA, Dbouk,HA, Ballou, LM, DeLeon, JL, Fan, Y, Chen, JS, Liang, Z, Li, G, Backer, JM,Lin, RZ, and Zong, WX. Class IA PI3-kinase p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Molecular Cell 2013 Apr; 50(1): 29-42.

Dbouk, HA and Backer, JM. Novel approaches to inhibitor design for the p110β PI3-KinaseTrends in Pharmacological Sciences 2013 Mar; 34(3): 149-153.

Dbouk, HA, Vadas, O, Williams, RL, and Backer JM. PI3Kβ downstream of GPCRs – Partners in Oncogenicity. Oncotarget 2012 Dec; 3(12): 1485-1486.

Dbouk, HA*, Vadas, O*,Shymanets, A, Burke, JE, Salamon, RS,Khalil, BD, Perisic, O, Shepherd, PR, Harteneck,C, Harden, TK, Smrcka, AV, Taussig, R,Bresnick, AR, Nürnberg, B, Williams, RL,and Backer, JM. G Protein-Coupled Receptor-mediated activation of p110β by Gβγis required for cellular transformation and invasiveness. Science Signaling 2012 Dec 4; 5, ra89.

Resume : Download
 
     
btm
 
 
top
 
 
 
 
 
btm

 
footer
 
 
home phone mail info@postdocjournal.com
 
twitter facebook social icon Social link You Tube sky
Click Here