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Dr. ALISON OBR
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Address 1
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Address 2
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Title
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Dr.
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First Name
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ALISON
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Last Name
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OBR
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University/Institution
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Rutgers University New Jersey Medical School
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Phone #
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973-972-0007
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Email ID
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alison.obr@rutgers.edu
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City
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Newark
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Country
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United States
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State
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New jersey
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Zipcode
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07103
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Department
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Cancer Center
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Company Name
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Area of Research
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Breast Cancer, Metastasis, and Cancer Immunology
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Area of Expertise
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Breast Cancer, Progesterone Signaling, IGF signaling, Metastasis, Mammary stem cells
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Brief Description of Research Interest :
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I am currently studying the role for loss of IGF signaling in breast cancer. Loss of IGF signaling leads to more aggressive, metastatic mammary tumors in the context of overexpressing an oncogene. Increased metastasis is correlated with increased expression of pro-inflammatory cytokines, M2 macrophage polarizing markers, and increased EMT marker expression. I am currently delineating the mechanism for metastasis in our model system.
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Representative Publications :
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Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP. Progesterone receptor and Stat5 signaling crosstalk through RANKLin mammary epithelial cells. Mol Endocrinol. 2013 Nov;27(11):1808-24.
Obr AE, Edwards DP. The biology of progesterone receptor in the normal mammary gland and in breast cancer. Mol Cell Endocrinol. 2012 Jun 24;357(1-2):4-17.
Grimm SL, Ward R, Obr AE, Franco HL,Fernandez-Valdivia R, Kim JS, Roberts JM, Jeong JW, DeMayo F, Lydon JP, Edwards DP, Wiegel NL. A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Mol Endocrinol. In Press.
Buser AC, Obr AE,Kabotyanski EB, Grimm SL, Rosen JM, Edwards DP. Progesterone receptor directlyinhibits β-casein gene transcription in mammary epithelial cells throughpromoting promoter and enhancer repressive chromatin modifications. Mol Endocrinol. 2011 Jun;25(6):955-68.
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Resume
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Download
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