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Dr. DEBJANI PAL
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Address 1
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Address 2
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Title
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Dr.
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First Name
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DEBJANI
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Last Name
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PAL
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University/Institution
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Ohio State University, Wexner Medical Center
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Email ID
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pald@miamioh.edu
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City
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Columbus
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Country
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United States
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State
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Ohio
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Zipcode
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44120
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Company Name
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Area of Research
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Cancer Biology
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Area of Expertise
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Cell Cycle, Cdh1, Tumorigenesis, Aneuploidy, Cancer Biology
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Brief Description of Research Interest :
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My expertise in protein biochemistry and cell biology laid the foundation for my current study as a postdoctoral fellow focusing on the control of genomic stability by specifically studying the regulation of chromosome segregation in mitosis, ultimately looking for key mitotic factors as potential novel anti-cancer therapeutic agents for drug development. Oncogene activity places increased stress in genome duplication and segregation machinery and subsequently a higher demand on the checkpoint to monitor them. Exploiting this inherent weakness by attacking these processes to induce additional stress is proventherapeutic strategy. By identifying novel factors regulating genome stability, we will gain important insight into the evolution of tumor cells and an improved understanding of how cells respond to current therapeutics. Recent work from my current lab suggests that spindle assemblycheckpoint (SAC) silencing is a highly dynamic and regulated process likely to be altered in cancer.
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Representative Publications :
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1. Pal D, Fite K*, Dabney-Smith C. (2013) Direct Interaction betweenPrecursor Mature Domain andTransport Component Tha4 during Twin Arginine Transport (Tat) of Chloroplasts. Plant Physiology. 161: 990-1001 (IF 8.030)
* undergraduate author
2. Summers MK and Pal D. (2017)The cooperative and antagonistic interplay of E3 ligases and deubiquitinating enzymes in genome maintenance (Book Chapter with InTech Publisher).
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