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Title : Dr.
First Name : BEN
Last Name : BAKONDI
Email ID : benjamin.bakondi@cshs.org
Country : United States
State : California
Zipcode : 90069
Department : Biomedical Science
Area of Research
Retinal degeneration
Area of Expertise
Stem cells & gene editing therapies
Brief Description of Research Interest :

My research focuses on defining stem cell mechanisms of tissue protection from disease and injury. I invested models of acute ischemic injury such as stroke and heart attack in my graduate studies, and in my postdoctoral training evaluate protection from progressive retinal diseases such as macular degeneration. I am also evaluating the use of CRISPR/Cas9 for in vivo gene therapy to treat dominant forms of inherited blindness including retinitis pigmentosa.

Representative Publications :

Bakondi B. In vivo versus ex vivo CRISPR therapies for retinal dystrophy. Expert Reviews of Ophthalmology. 2016 Nov;11(6):397-400. Doi:10.1080/17469899.2016.1251316

Bakondi B, Girman S, Lu B, Wang S. Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection from Retinal Degeneration and Vision Loss. Stem Cells Translational Medicine2017 Feb;6(2):444-457. Doi:10.5966/sctm.2016-0181

Bakondi B*, Lv W*, Lu B, Jones MK, Tsai Y, Kim KJ, Levy R, Akhtar AA, Breunig JJ, Svendsen CN, Wang S. In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in theS334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa. Molecular Therapy. 2016 24(3):556-563. Equal contribution. Doi:10.1038/mt.2015.220

Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. Human iPSC-derived neural progenitor cells preserve vision in a preclinical model of AMD. Stem Cells. 2015 33(8);2537-2549. Doi:10.1002/stem.2032

Bakondi B, Shimada IS, Peterson BM, and Spees JL. SDF-1 secreted by CD133-derived MSCs promotes neural progenitor cell survival through CXCR7. Stem Cells & Development. 2011 Jun;20(6):1021-1029. Doi:10.1089/scd.2010.0198

Bakondi B, and Spees, JL. Human CD133-derived bone marrow stromal cells establish ectopic hematopoietic microenvironments in immunodeficient mice. Biochemical and Biophysical Research Communications. 2010 Sep;400(2):212-218. Doi:10.1016/j.bbrc.2010.08.040

Bakondi B*, Shimada* IS, Perry A, Munoz JR, Ylostalo J, Howard AB, Gregory CA, and Spees JL. CD133 identifies a human bone marrow stem/progenitor cell subpopulation with a repertoire of secreted factors that protect against stroke. Molecular Therapy. 2009 17:1938-1947. *Equal contribution. Doi:10.1038/mt.2009.185


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