A Journal of Postdoctoral Research.
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Designer 3D DNA polyhedra for biomedical applications
Dhiraj Bhatia
Institute Curie
Centre de Recherche, U1143/UMR3666, INSERM/Curie/CNRS, 26 rue d’Ulm, 75248 Paris Cedex 05, France


Structural DNA nanotechnology explores various nanoscale structural and functional properties of DNA to develop probes at nanoscale for diverse applications. Three dimensional architectures based on DNA like various polyhedra, boxes, and DNA-based dendrimers, have raised particular interest in biomedical applications. Some of these DNA architectures have been recently explored as nano containers for functional molecules and as molecular scaffolds to site specifically display biological ligands. Such DNA nanostructures have been demonstrated to interact with cell-surface markers and trigger signalling pathways in biological systems via specific targets. These recent studies highlight the emerging potential of DNA devices in biomedical applications that could enable targeted delivery of molecular payloads within living systems.


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