A Journal of Postdoctoral Research.
     Login   |   Register   
    ISSN : 2328-9791
left right
Adeno-Associated Viral Vector Delivery to the Enteric Nervous System: A Review
Sara E. Gombash
The Ohio State University
Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA

Gene therapy to the gastrointestinal tract has remarkable potential for treating gastrointestinal disorders that currently lack effective treatments. Adeno-associated viral vectors (AAVs) have been extensively applied to the central nervous system, and have repeatedly demonstrated safety and efficacy in animal models. The enteric nervous system (ENS) represents a vast collection of neurons and glial cells that may also be subject to treatment by AAV, however little work has been conducted on AAV delivery to the ENS. Challenges for gastrointestinal gene therapy include identifying gene targets, optimizing gene delivery, and target cell selection. Researchers are now beginning to tackle the later of the two challenges with AAV, and the same AAV technology can be used to identify novel gene targets in the future. Continued efforts to understand AAV delivery and improve vector design are essential for therapeutic development. This review summarizes the current knowledge about AAV delivery to the ENS.


home phone mail info@postdocjournal.com
twitter facebook social icon Social link You Tube sky
Click Here