A Journal of Postdoctoral Research.
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Entangled but Finicky Ingression Protein Complexes for Successful Cytokinesis
Maria Angeles Juanes, Ph.D.
Brandeis University
Rosenstiel Center, Brandeis University, 415 South Street, Waltham, MA 02454, USA

Cytokinesis is the final stage of mitosis that leads to the physical separation of two daughter cells and comprises a sequence of events such as actomyosin ring contraction, ingression and remodeling of the extracellular matrix. All these processes are tightly regulated in space and time through a network of proteins. Defects in cytokinesis may increase the risk of tumor formation. Using a combination of cell biology and molecular techniques, along with biochemical experiments, Foltman et al. [27] have dissected how the “ingression protein complexes” (IPCs) localize and coordinate to ensure proper cytokinesis. Interestingly, a particular glycosyltransferase, named Chs2, is the hub protein that assures a successful cytokinesis in budding yeast.


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