A Journal of Postdoctoral Research.
     Login   |   Register   
    ISSN : 2328-9791
left right
Regulatory function of membrane trafficking components in exosome secretion and cancer pr
Aditya Kulkarni, PhD
University of Texas Southwestern Medical Center
Department of Biochemistry, UTSMC, Dallas TX 75390-9038, USA

Cancer cell-derived exosomes have recently been implicated in contributing to metastasis. It is expectable that specific membrane trafficking factors would participate in the regulation of exosome formation, transport and release from cells. Recent investigations have revealed certain members belonging to the SNARE, sorting factor and Rab GTPase protein families as being crucial in governing the exosome life cycle. These trafficking components have therefore been primed as new targets potentially modulating cancer progression. This mini-review is focused on the involvement of membrane trafficking components in regulating exosome-related transport and signaling, and in turn influencing clinical outcomes in cancer.


home phone mail info@postdocjournal.com
twitter facebook social icon Social link You Tube sky
Click Here