log  
logo
a Journal of Postdoctoral Research and Postdoctoral Affairs.
 
     Login   |   Register   
    ISSN : 2328-9791 Contact Us
left right
 
 
Jadomycins: A Study of Their Synthesis and Biological Evaluation
     
 
Ehesan U. Sharif, PhD, and George A. O’Doherty, PhD
Arcus Biosciences, and Northeastern University
Arcus Biosciences, 3928 Point Eden Way, Hayward, CA 94545, USA
Northeastern University, Boston, MA 02125, USA
ehesan.sharif@gmail.com

Jadomycins are anticancer antibiotics isolated from Streptomyces venezuelae. The core of these natural products consists of a dihydro-phenanthridine ring-system. Another unique feature built to the core is a fused 1,3-oxazolidine-5-one ring. Recent synthetic reports suggest a structural revision of the fused oxazolidinone ring in jadomycin S and jadomycin T. This review will focus on the synthetic efforts leading to the structural revision, and the semisynthetic approaches to generate new jadomycin analogs and their biological activity.

 
btm
 
Discussion Board
 
Comments
 
     
btm
 
 
 
top
 
 
 
btm
top
btm

 
submit_article Announcements
 
submit_article Submit Your Article
 
submit_article Post your Job
footer
 
 
home phone mail info@postdocjournal.com
 
twitter facebook social icon Social link You Tube sky
Click Here