A Journal of Postdoctoral Research.
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The first architecture of telomerase holoenzyme
Bo Liang
Harvard Medical School
Department of Biological Chemistry and Molecular Pharmacology, HHMI/Harvard Medical School,
Boston, MA, USA
Telomerase is a reverse transcriptase that maintains genome integrity by adding DNA repeats to chromosome ends called telomeres. Ever since the discovery of telomerase in Tetrahymena by Carol W. Greider and Elizabeth Blackburn in 1984, the telomerase holoenzyme drew great attention due to its central roles in regulating stem cell renewal and the immortality of many cancer cell types. Despite expanded studies of telomerase function in many organisms, little was known about the molecular architecture of telomerase holoenzyme. Because of its low abundance and complexity, the purification and reconstitution of homogeneous telomerase holoenzyme has consistently presented a challenge for structural studies.....

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