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New pigmentation genes linked to iris transillumination defects in BXD glaucoma murine st
     
 
Shankar Swaminathan, Hong Lu, Robert W. Williams, Lu Lu, and Monica M. Jablonski.
University of Tennessee, Memphis, TN: Nantong University, Nantong, China
University of Tennessee Health Science Center, Memphis, TN: Nantong University, Nantong, China


sswamin4@uthsc.edu
The iris and iridial melanin are important influencers of vision. The mouse iris, due to its dense pigmentation, is unique and presents a powerful opportunity for studying pigment cell biology. Pigmentation abnormalities are clinically significant; as they can lead to albinism, iris transillumination defects (TIDs), and potentially pigment dispersion glaucoma. Despite its well-­‐ documented biological significance, there is a clear knowledge gap surrounding the basic molecular and cellular processes influencing pigmentation of the iris. It is a complex genetic trait controlled by an intricate network of genes whose coordination and regulation are poorly understood.
 
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