Fluoroform (CF3H): An Industrial Waste or a Useful Raw Material?

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ISSN : 2328-9791

Fluoroform (CF3H): An Industrial Waste or a Useful Raw Material?

Parag V. Jog and G. K. Surya Prakash.

University of Southern California

Loker Hydrocarbon Research Institute University of Southern California, Los Angeles, CA, USA.

pjog@usc.edu

Trifluoromethylated compounds have received great attention in organofluorine chemistry because of a variety of applications in the fields of drug discovery, material chemistry and polymer chemistry. There are many available reagents (electrophilic, nucleophilic and radical- based), which can be used to introduce trifluoromethyl group in a given molecule. Fluoroform (CF3H) is one the most simple and cheap sources of trifluoromethyl group. In this review, we briefly summarize some important research and development efforts in past two decades where chemists have used fluoroform as a source of trifluoromethyl group to synthesize a variety of trifluoromethylated products.