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Mesenchymal stem cells: the truth about their nature, origin and potential use for therap
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Leah Cook
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H. Lee Moffitt Cancer Center
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Department of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
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leah.cook@moffitt.org
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About 0.001% to 0.01% of the bone marrow compartment is comprised of mesenchymal stem cells (MSCs). MSCs are distinct from hematopoietic stem cells (which differentiate into blood lineage and immune cells) in that they differentiate into fibroblasts, chondrocytes, myocytes, adipocytes, or osteoblasts, and are involved in the maintenance and regeneration of connective tissues, cartilage, muscle, fat tissue and bone, respectively MSCs are multipotent, have limitless proliferative abilities, and can home to sites of tissue injury for repair [1, 2]. The microenvironment of solid tumors closely resembles that of injured tissue, producing chemokines that can recruit MSCs to the tumor site. There have been conflicting data....
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