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Research Highlight : Morphogen Signaling—Filopodia Pave the Way
Rajprasad Loganathan
The Johns Hopkins University School of Medicine
Department of Cell biology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Morphogen signaling is critical for pattern formation during embryogenesis. The concept of morphogens originated from the results of classic embryology experiments performed nearly a century ago by Morgan and Boveri (Lawrence, 2001). A century of work, and still ongoing, morphogens are understood to be signaling molecules diffusing out in a monotonic concentration gradient from the source cells, and influencing the developmental fate of recipient cells in a strictly concentration-dependent manner. Despite our challenges in precisely defining the core set of features that characterize morphogens, the concept of morphogen signaling remains a cornerstone in developmental biology that has led to major breakthroughs in our understanding of the cell biology of animal development.

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