One-pot synthesis protocol for highly functionalized benzofuran scaffold

A Journal of Postdoctoral Research.

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ISSN : 2328-9791

One-pot synthesis protocol for highly functionalized benzofuran scaffold

Preetpal S Sidhu

University of Wisconsin

Department of Chemistry and Biochemistry, University of Wisconsin, Milwaukee, WI 53211, USA

Sidhup@uwm.edu

Benzofuran scaffold appears frequently in natural products, commercial libraries, biologically and pharmaceutically relevant compounds. The presence of substituent handles help to diversify the structure further. Various classes of reactions such as enzyme-catalyzed, transition metal-catalyzed, base, acid and photochemical-induced cyclization were reported in the last few decades. Several modified protocols such as microwave-based and solid-phase reactions are recently reported with improved yield and scope of the reaction. This review provides an insight into one-pot transformation reactions for synthesis of functionalized benzofuran scaffold.