Let There Be Light Activated Drug Release | Society of Life Sciences (SoLS)

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ISSN : 2328-9791

Let There Be Light Activated Drug Release

Stephan C. Jahn

University of Florida

Department of Medicinal Chemistry and UF Health Cancer Center, UFL, Gainesville, FL 32610, USA

scjahn@ufl.edu

In some instances systemic drug delivery, either orally or intravenously, may not be the ideal dosing strategy. Repeated intravenous injections are unpleasant and sometimes a more localized delivery is needed such as in treatment of a tumor. A method that would allow a reservoir of drug to be implanted in a patient and be released in a controlled manner on demand would allow repeated dosing in a localized area and could prove extremely beneficial in the clinic by limiting the total dose needed and therefore the related side effects. The present article highlights a new approach utilizing reservoir capped by a light-responsive membrane that can be made permeable using an external near-infrared light source that was recently published by Timko et al.