A Journal of Postdoctoral Research.
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    ISSN : 2328-9791
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Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases
Yiming Zhong, Amy J. Johnson, John C. Byrd, and Jason A. Dubovsky
The Ohio State University
Division of Hematology, Department of Internal Medicine, OSU, 320 W. 10th Avenue, Columbus, OH 43210, USA

IL2-inducible T-cell kinase (ITK), a member of the Tec family tyrosine kinases, is the predominant Tec kinase in T cells and natural killer (NK) cells mediating T cell receptor (TCR) and Fc receptor (Fc R) initiated signal transduction. ITK deficiency results in impaired T and NK cell functions, leading to various disorders including malignancies, inflammation, and autoimmune diseases. In this mini-review, the role of ITK in Tcell signaling and the development of small molecule inhibitors of ITK for the treatment of T-cell related disorders is examined.


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