A Journal of Postdoctoral Research.
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    ISSN : 2328-9791
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The Wnt/ß-catenin Signaling Pathway in Epithelial Mesenchymal Transition
Mitchell E. Menezes
Virginia Commonwealth University
Department of Human and Molecular Genetics, VCU, 1220 East Broad Street, Richmond, VA 23298, USA

Epithelial mesenchymal transition (EMT) is a well conserved process by which polarized, immotile epithelial cells transition into motile mesenchymal cells. EMT plays an important role during normal biological processes such as embryogenesis and wound healing. More recently, EMT has been studied for its role in cancer progression and metastasis. Understanding the molecular mechanisms that regulate EMT are key to developing novel therapeutic interventions for cancer. Dysregulated or uncontrolled activation of the Wnt/β-catenin signaling pathway promotes tumor progression and metastasis. The Wnt/β-catenin signaling pathway is one of the signaling pathways that has been implicated in EMT. In this review, major Wnt target genes that promote EMT as well as the various antagonists and microRNAs that regulate the Wnt/β-catenin pathway to influence EMT during cancer progression will be discussed.


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