A Journal of Postdoctoral Research.
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    ISSN : 2328-9791
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Soluble Adenylyl Cyclase (sAC) Rescues Neurons from Inhibitory Myelin Cues
Ambika Chandrasekhar, PhD, and Anand Krishnan, PhD
University of Alberta

Alberta Diabetes Institute and Division of Neurology, Faculty of Medicine,UA, 116 St and 85Ave, Edmonton, AB T6G 2R3, Canada

Myelin associated proteins are known to pose hurdles to central nervous system (CNS) axon regeneration. The myelin mediated inhibition on axon regeneration can be reversed by brain derived neurotrophic factor (BDNF). BDNF enhances cyclic AMP (cAMP) levels for eliciting its beneficial effects on axon regeneration. A recent article by Martinez et al., revealed that soluble adenylyl cyclase (sAC) is a potential catalytic source for cAMP in BDNF stimulated neurons. Interestingly BDNF stimulated or exogenously administered sAC was able to reverse the inhibitory effects of myelin on axon regeneration suggesting that sAC is a potential therapeutic opportunity in CNS injury.


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