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Home > Editorial-Board > Dr.MAURIZIO PELLEGRINO

Dr.MAURIZIO PELLEGRINO

Address 1	:
Address 2	:
Title	:	Dr.
First Name	:	MAURIZIO
Last Name	:	PELLEGRINO
University/Institution	:	University of California, Berkeley
Email ID	:	mpellegri@berkeley.edu
City	:	Berkeley
Country	:	United States
State	:	CALIFORNIA
Zipcode	:	94704

Member of the Executive Board.

Department	:	Molecular and Cell Biology
Company Name	:
Area of Research
Neuroscience

Brief Description of Research Interest :
I am interested in sensory systems, to understand how organisms perceive the outside world and transform external inputs into internal representations of their environment. My graduate work focused on the insect olfactory system. Olfactory receptor proteins expressed in insects sensory neurons detect volatile chemicals in the environment. My graduate research helped classify these proteins as part of a family of ion channels, contrary to the belief that they belonged to the superfamily of GPCRs like the olfactory receptors employed by mammals and nematodes. In addition, we described that insect olfactory receptors are a molecular target of the insect repellent DEET, therefore opening up new possibilities for the design of better insect repellents. During my postdoctoral training, I plan to investigate the molecular mechanisms underlying the sensation of touch in mammals. While some of the molecules involved in somatosensation have been recently described, those involved in mechanotransduction are still largely unknown. In addition to basic research, I am interested in policy and in the way science and society interact and influence each other.
Representative Publications :
Pellegrino M., Nakagawa T., Vosshall L.B. 2010 Single sensillum recordings in the insects Drosophila melanogaster and Anopheles gambiae. JoVE 36. http://www.jove.com/index/details.stp?id=1725, doi:10.3791/1725 PellegrinoM., Nakagawa T. 2009 Smelling the difference: controversial ideas in insect olfaction. J. Exp. Biol. 212:1973-1979. Sato K., Pellegrino M., Nakagawa T., Nakagawa T., Vosshall L.B., Touhara K. 2008 Insect olfactory receptors are heteromeric ligand-gated ion channels. Nature452:1002-1006. Ditzen M., Pellegrino M., Vosshall L.B. 2008 Insect odorant receptors are molecular targets of the insect repellent DEET. Science 319:1838-1842. Camera P., Schubert V., Pellegrino M., Berto G., Vercelli A., Muzzi P., Hirsch E., Altruda F., Dotti C.G., Di Cunto F. 2008 The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments. EMBO Rep. 9:384-392. Fagoonee S., Di Cunto F., Vozzi D., Volinia S., Pellegrino M., Gasparini P., Silengo L., Altruda F., Tolosano E. 2006 Microarray and large-scale in silico-based identification of genes functionally related to Haptoglobin and/or Hemopexin. DNA Cell Biol. 25:323-330. Suarez-Farinas M., Pellegrino M., Wittkowsky K.M., Magnasco M.O. 2005 Harshlight: a ‘corrective make-up’ program for microarray chips. BMC Bioinformatics 6:294. *these authors contributed equallyto the work Pellegrino M., Provero P., Silengo L., Di Cunto F. 2004 CLOE: Identification of putative functional relationships among genes by comparison of expression profiles between two species. BMC Bioinformatics5:179. Retta S.F., Cassarà G., D’Amato M., Alessandro R., Pellegrino M.,Degani S., De Leo G., Silengo L., Tarone G. 2001 Cross Talk between beta1 andalphaV Integrins: beta1 Affects beta3 mRNA Stability. Mol. Biol. Cell 12:3126-3138.
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