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    ISSN : 2328-9791
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  Dr. AJAY YEKKIRALA  
 
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Title : Dr.
First Name : AJAY
Last Name : YEKKIRALA
University/Institution : Harvard medical school/Children's hospital Boston
Email ID : ajay.yekkirala@childrens.harvard.edu
City : Boston
Country : United States
State : Massachusetts
Zipcode : 02155
Department : Neurobiology
Company Name :
Area of Research
Pain, nociception, peripheral nerve regeneration
Area of Expertise
Neuroscience, pharmacology, medicinal chemistry
Brief Description of Research Interest :
The main objective of my research is to identify molecular mechanisms involved in pain. We are currently focused on elucidating the signaling cross-talk between neuropeptide G protein coupled receptors (GPCRs) and transient receptor potential (TRP) ion channels in the context of inflammatory and neuropathic pain. We are also using proteomics to identify proteins that that are involved in peripheral nerve regeneration. In addition, we are using high-throughput screening assays to develop small molecule compounds as analgesic therapeutics.
Representative Publications :

Book chapters:

1. Besemann, C.,Denton, A., Yekkirala, A., Hutchison, R.S., and Anderson, M.A. (2006)

DifferentialAssociation Rules: Understanding Annotations in Protein Interaction Networks.In Advanced Data Mining Technologies in Bioinformatics  (Hui-Huang Hsu, Ed.) pg 269-282, IdeaGroup Inc.

 

2. Besemann, C.,Denton, A., Yekkirala, A., Hutchison, R.S., and Anderson, M.A. (2007)

DifferentialAssociation Rules: Understanding Annotations in Protein Interaction Networks.In Intelligent Information Technologies: Concepts, Methodologies, Tools andApplications, Volumes 1-4, (Sugumaran, V, Ed.), pg 620-630, Idea Group Inc.

 

Research Papers:

1. Liu, H., Ladage,K., Iyer, J., Yekkirala, A., and Hutchison, R.S. (2004) Targetedscreening for PsbO mutations in Chlamydomonas reinhardtii. In Photosynthesis:Fundamental Aspects to Global Perspectives, Proceedingsof the 13th International Congress on Photosynthesis. ACG Publishing,Lawrence, KS

 

2. Besemann, C.,Denton, A., Yekkirala, A., Hutchison, R.S., and Anderson, M.A. (2004)

DifferentialAssociation Rule Mining for the Study of Protein-Protein Interaction Networks. In proceedings 4th Workshop on DataMining in Bioinformatics in conjunction with The Tenth ACM SIGKDD InternationalConference on Knowledge Discovery and Data Mining. Seattle, WA, USA

 

3. Lunzer, M., Yekkirala,A., Hebbel, R. P. and Portoghese, P.S. (2007) Naloxone acts as a potent analgesicin mice with sickle cell disease. Proc.Natl. Acad. Sci., USA. 104, 6061-6065.

 

4. Zhang, S., Yekkirala,A. S., Tang, Y. & Portoghese P. S. (2009) A bivalent ligand (KMN-21)antagonist for μ/κ heterodimeric opioid receptors. Bioorg.Med. Chem. Lett. 19, 6978-6980.

 

5. Yekkirala, A.S., Kalyuzhny, A. E. & Portoghese, P. S. (2009) Standard OpioidAgonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and[d-Ala2-MePhe4-Glyol5] Enkephalin as Selective μ−δ Agonists. ACS Chem. Neurosci., 1,146 – 154.

 

6. Yekkirala, A.S., Lunzer, M. M., McCurdy, C. R., Powers, M. P., Roerig, S. C. &Portoghese, P. S. (2011) N-Naphthoyl-β-naltrexamine (NNTA), a selective activatorof μ/κ opioid receptor heteromers. Proc.Natl. Acad. Sci. USA. DOI: 10.1073/pnas.1016277108

 

7. Metcalf, M., Yekkirala,A. S., Powers, M. D., Kitto, K., Fairbanks, C. A., Wilcox, G. L., andPortoghese, P. S. (2012) The δ Opioid Receptor Agonist SNC80 SelectivelyActivates Heteromeric μ–δ Opioid Receptors. ACS Chem. Neurosci. DOI: 10.1021/cn3000394

 

8. Yekkirala, A. S. (2012) Two to tango: GPCR oligomers and GPCR-TRP channel interactionsin nociception. Life Sci. (in press)

 

9. Yekkirala, A. S., Banks, M. L., Negus, S. S., Rice, K. C. & Portoghese, P. S. (2011) Narcotic analgesics selectively activate μ-δ opioid heteromers in rhesus monkeys. ACS Chem. Neurosci. (in press)
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