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Dr. SARAH RATCLIFFE
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Address 1
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Address 2
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Title
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Dr.
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First Name
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SARAH
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Last Name
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RATCLIFFE
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University/Institution
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University of Bristol
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Email ID
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sarah.ratcliffe@bristol.ac.uk
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City
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Bristol
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Country
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United Kingdom
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State
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Avon
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Zipcode
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BS8 1TD
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Department
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School of Biochemistry
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Company Name
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Area of Research
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Membrane Protein Biochemistry
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Area of Expertise
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Silicon Transporters
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Brief Description of Research Interest :
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I gained an honors degree in Medical Sciences from the University of Birmingham with my final year spent speciailising in Medical and Molecular Genetics as well as Viral Oncology. Then (following a year spent in the pharmaceutical industry) I focused more on molecular biology with a PhD at the University of Cambridge with the aim of identifying silicon-responsive genes, preferably silicon transporters in the rat genome with the hope to link this to human genes.The main research for this was carried out at the Medical Research Council but along the way I set up collaborations and undertook work at Wageningen University, The Netherlands, Department of Zoology, University of Cambridge, and both The Gurdon and Babraham Institutes in Cambridge. As part of my research rat tissue was used to isolate candidate genes, using specialist gene arrays, for silicon transport, and protein expression studies (using both Xenopus oocyte and Baculoviral-insect cell models) were subsequently carried out. Silicon is abundant in our diets and previous studies suggest that it has an important role in the health and development of bone and connective tissues. The identification of silicon transporter(s) in mammals will be an hugely important contribution to the field as of yet the biochemical pathways of dietary silicon in mammals are unknown and therefore the role it plays in bone health (for example the striking increase in bone mineral density in premenopausal with increasing dietary silicon intake) is not currently fully understood. With the growing problem of diseases such as osteoporosis on a global scale having the answers to these questions could have a huge impact on public health.
I have recently started a postdoc at the University of Bristol where I am focusing my research on silicon transporters in the marine diatom Thalassiosira pseudonana. Diatoms have unique and incredibly detailed silica cell walls/shells which are of great interest for their nano-technological applications. Understanding the biochemistry behind the uptake of silicon and control of its deposition in such intricate patterns would allow for these pathways to be exploited and used in vitro.
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Representative Publications :
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Resume
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Download
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