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Dr. NICOLE BILLINGS
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Address 1
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Address 2
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Title
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Dr.
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First Name
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NICOLE
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Last Name
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BILLINGS
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University/Institution
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Massachusetts Institute of Technology
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Email ID
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anb11@mit.edu
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City
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Cambridge
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Country
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United States
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State
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Massachusetts
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Zipcode
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02139
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Department
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Biological Engineering
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Company Name
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Area of Research
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Microbial biofilms; particle mobility in mucus hydrogels
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Area of Expertise
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Microbiology/Microscopy
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Brief Description of Research Interest :
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My research interests include a greater understanding of the selective barrier and adhesive properties of biological hydrogels. In my previous graduate work, I investigated the role of a chemotaxis-like pathway, Che1, in remodeling of the extracellular matrix of Azospirillum brasilense during flocculation and biofilm formation. My current Postdoctoral research focuses on the contribution of Pseudomonas aeruginosa extracellular polysaccharides, Pel, Psl, and alginate, to antibiotic resistance and nutrient acquisition during early onset biofilm infection models. Additional projects include probing the permeability properties of mucus hydrogels for fine-tuned, customizable drug delivery systems.
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Representative Publications :
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1. Billings, A.N.*, Millan, M.R., Caldara, M., Rusconi R., Terasova, Y., Stocker, R., Ribbeck K. “The matrix component Psl is a major determinant for antibiotic resistance of Pseudomonas aeruginosa biofilms”Currently in review.
2. Siuti P., Green C., Edwards A.N.*, Doktycz M. J., Alexandre G., (2011) “The chemotaxis-like Che1 pathway has an indirect role in adhesive cell properties of Azospirillum brasilense” FEMS Microbiology Letters 323 (2)105-112.
3. EdwardsA.N.*, Siuti P., Bible A.N., Alexandre G., Retterer S.T., Doktycz M.J., Morrell-Falvey J. L. (2011) “Characterization of Cell Surfaceand Extracellular Matrix Remodeling of Azospirillumbrasilense Chemotaxis-like 1 Signal Transduction Pathway mutants by AtomicForce Microscopy.” FEMS Microbiology Letters 314(2) 131-139.
4. Edwards A.N.*, Fowlkes, J.D., Owens, E.T., Standaert,R.F., Pelletier,D.A., Hurst G.B., Doktycz,M.J., Morrell-Falvey, J.L. (2009) “An in vivoimaging-based assay for detecting protein interactions over a wide range of binding affinities.” Analytical Biochemistry 395(2), 166-177.
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